Results 51 to 60 of about 4,075,413 (333)
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
The aleatoric aspect of literary tourism: an example from Havana
Tourism, 2020 The expression literary tourism is an established term which rarely raises controversies. It fits well into a positivist way of thinking about tourism reality.
Jacek Kaczmarek
doaj +1 more source
Did the Universe Have a Chance? [PDF]
, 2018 In a world awash in statistical patterns, should we conclude that the universe’s evolution or genesis is somehow subject to chance? I draw attention to alternatives that must be acknowledged if we are to have an adequate assessment of what chance the ...
McCoy, C. D.
core +4 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Making sense of (exceptional) causal relations. A cross-cultural and cross-linguistic study
Frontiers in Psychology, 2015 In order to make sense of the world, humans tend to see causation almost everywhere. Although most causal relations may seem straightforward, they are not always construed in the same way cross-culturally.
Olivier eLe Guen +4 more
doaj +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Nature CommunicationsTumor heterogeneity and tumor evolution contribute to cancer treatment failure. To understand how selective pressures drive heterogeneous tumor evolution, it would be useful to image multiple important components and tumor subclones in vivo. We propose a
Xiujuan Gao +12 more
doaj +1 more source
, 1996 By detailed consideration of the mapping \(h:[0,1]\to [0,1]\) defined by \[ h(x)= \min\{x/c,(1-x)/(1-c)\},\quad c\in(0,1), \] the author shows that chance and chaos may be seen as different aspects of the same phenomenon, in which case randomness may be used to explain chaos. A main ingredient in chaos, viz.
openaire +4 more sources
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source