Results 81 to 90 of about 3,930,802 (359)
FEBS Letters, EarlyView.Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek +15 more
wiley +1 more source
Chance Constraint Tuning for Optimal Power Flow [PDF]
arXiv, 2020 In this paper, we consider a chance-constrained formulation of the optimal power flow problem to handle uncertainties resulting from renewable generation and load variability. We propose a tuning method that iterates between solving an approximated reformulation of the optimization problem and using a posteriori sample-based evaluations to refine the ...
arxiv
La composante darwinienne et la philosophie de Bergson dans la poésie de Thomas Hardy
Miranda: Revue Pluridisciplinaire du Monde Anglophone, 2010 This article addresses the affinities between Henri Bergson's philosophy and Thomas Hardy's poetry. Both draw upon Charles Darwin's theories of natural science : Hardy was greatly influenced by them, whereas Bergson transmuted Darwinism as his élan vital
Ilaria Mallozi
doaj +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
The Role of a Personality in Historical and Political Process
Historia i Polityka, 2019 The article presents the analysis of such concepts as “historical regularity”, “chance” and “great personality”. It is stressed that while studying epistemological problems of historical science we must focus on the system categories being used in ...
Basil Kozma
doaj +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Iterative Decomposition of Joint Chance Constraints in OPF [PDF]
arXiv, 2020 In chance-constrained OPF models, joint chance constraints (JCCs) offer a stronger guarantee on security compared to single chance constraints (SCCs). Using Boole's inequality or its improved versions to decompose JCCs into SCCs is popular, yet the conservativeness introduced is still significant. In this letter, a non-parametric iterative framework is
arxiv
Nature Communications, 2019 Liver sinusoidal endothelial cells are known to promote immune tolerance in liver. Here, the authors target these cells using melittin nanoparticles and show alterations in the liver immune environment and suppression of liver metastases.
Xiang Yu +7 more
doaj +1 more source
Chance in the Modern Synthesis [PDF]
, 2016 The modern synthesis in evolutionary biology is taken to be that period in which a consensus developed among biologists about the major causes of evolution, a consensus that informed research in evolutionary biology for at ...
Matthews, Lucas John +3 more
core
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source