Results 81 to 90 of about 2,459,786 (308)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Fleet routing and scheduling problem based on constraints of chance
Advances in Mechanical Engineering, 2017 Tramp shipping transport is an important part of ocean transportation. However, facing the spot market with many uncertain conditions, it is not easy for fleet operators to plan vessel’s routes and schedule in the later period time, especially ...
Feng Guan +4 more
doaj +1 more source
A Decomposition Algorithm for the Two-Stage Chance-Constrained Operating Room Scheduling Problem
IEEE Access, 2020 The required time for surgical interventions in operating rooms (OR) may vary significantly from the predicted values depending on the type of operations being performed, the surgical team, and the patient.
Amirhossein Najjarbashi, Gino J. Lim
doaj +1 more source
Robust Beamforming for SWIPT System with Chance Constraints [PDF]
2018 IEEE International Conference on Communications (ICC), 2018 The robust beamforming problem in multiple-input single-output (MISO) downlink networks of simultaneous wireless information and power transfer (SWIPT) is studied in this paper. Adopting the time switching fashion to perform energy harvesting and information decoding respectively, we aim at maximizing the sum rate under imperfect channel state ...
Yinglei Teng +4 more
openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Distributionally robust scheduling method for islanded microgrids considering frequency security
电力工程技术The frequency security of islanded microgrids is addressed through a distributionally robust scheduling method that optimizes heterogeneous frequency regulation resources, including generation sources, storage systems, and loads.
Juan LIU +5 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Early‐Phase Research in Pediatric Neuro‐Oncology
Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source