Results 111 to 120 of about 954 (226)

Long-Short-Term Memory in Active Wavefield Geophysical Methods [PDF]

The PhD thesis discusses the application of Long Short-Term Memory (LSTM) networks in active wavefield geophysical methods. In this work we emphasizes the advantages of Deep Learning (DL) techniques in geophysics, such as improved accuracy, handling ...
RONCORONI, GIACOMO
core  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Multi-Platform Integrated Analysis of the Degradation Patterns of Impact Crater Populations on the Lunar Surface

Remote Sensing
Following the processing of the Chang’e-4 satellite images, Chang’e-4 landing camera images, and Yutu-2 panoramic camera images, data were obtained in a variety of resolutions, including digital elevation model (DEM) and digital orthophoto map (DOM).
Meixi Chen, Xinyu Ma, Teng Hu, Zhizhong Kang, Meng Xiao   +4 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Lunar rock investigation and tri-aspect characterization of lunar farside regolith by a digital twin

Nature Communications
Yutu-2 rover conducted an exciting expedition on the 41st lunar day to investigate a fin-shaped rock at Longji site (45.44°S, 177.56°E) by extending its locomotion margin on perilous peaks.
Liang Ding, Ruyi Zhou, Tianyi Yu, Huaiguang Yang, Ximing He, Haibo Gao, Juntao Wang, Ye Yuan, Jia Wang, Zhengyin Wang, Huanan Qi, Jian Li, Wenhao Feng, Xin Li, Chuankai Liu, Shaojin Han, Xiaojia Zeng, Yu-Yan Sara Zhao, Guangjun Liu, Wenhui Wan, Yuedong Zhang, Saijin Wang, Lichun Li, Zongquan Deng, Jianzhong Liu, Guolin Hu, Rui Zhao, Kuan Zhang   +27 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The Moon's farside shallow subsurface structure unveiled by Chang'E-4 Lunar Penetrating Radar. [PDF]

Sci Adv, 2020
Li C, Su Y, Pettinelli E, Xing S, Ding C, Liu J, Ren X, Lauro SE, Soldovieri F, Zeng X, Gao X, Chen W, Dai S, Liu D, Zhang G, Zuo W, Wen W, Zhang Z, Zhang X, Zhang H.   +19 more
europepmc   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source