Results 121 to 130 of about 2,624,164 (273)

Sequential Change-point Detection for High-dimensional and non-Euclidean Data

, 2018
In many modern applications, high-dimensional/non-Euclidean data sequences are collected to study complicated phenomena over time and it is of scientific importance to detect anomaly events as the data are being collected.
Chen, Hao, Chu, Lynna
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Robust Nonparametric Early Stopping in Tree Ensembles via IQR-Scale Change-Point Detection

Mathematics
Tree ensembles—Random Forests (RFs) and Gradient Boosting Machines (GBMs)—often stabilize before all trees are evaluated. We study early stopping as a nonparametric change-point problem on prediction increments.
Sooyoung Jang, Changbeom Choi
doaj   +1 more source

Change detection in SAR time-series based on the coefficient of variation

, 2019
This paper discusses change detection in SAR time-series. Firstly, several statistical properties of the coefficient of variation highlight its pertinence for change detection. Then several criteria are proposed. The coefficient of variation is suggested
Koeniguer, Elise Colin, Nicolas, Jean-Marie   +1 more
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Extreme change-point detection

We examine rules for predicting whether a point in $\mathbb{R}$ generated from a 50-50 mixture of two different probability distributions came from one distribution or the other, given limited (or no) information on the two distributions, and, as clues, one point generated randomly from each of the two distributions.
openaire   +2 more sources

Intelligent Interface Detection of Frozen Rock Masses Using Measurement While Drilling Data and Change-Point Analysis

Sensors
To address the critical challenges of lithology acquisition and low blasting refinement under extreme low temperatures and varying thermal conditions in high-altitude environments, this study develops a real-time dynamic identification method for rock ...
Fei Gao, Hui Chen, Xiujun Wu, Huijie Zhai, Yuanxiang Mu   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source