Results 211 to 220 of about 21,529,539 (291)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Climate change and infectious diseases: translating evidence into action. [PDF]

Infect Dis Poverty
Shi X, Li T, Wang Y, Liu Q, Wang J, Ban J, Kinney PL, Tong S.   +7 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Climate change impact on future Egypt's wind energy: a CMIP6-based assessment of power output. [PDF]

Sci Rep
Hamed MM, Sobh MT, El-Mallawany AR, Elgharib AO.   +3 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

A Phenomenological Analysis of Knowledge, Impact and Coping Strategies to Climate Change: Experiences of Persons With Albinism. [PDF]

Public Health Chall
Nkosi BN, Esinam SC, Selase AF, Sarah A, Wilson AE.   +4 more
europepmc   +1 more source

For a Change …

Journal of the Royal College of Physicians of London, 1992
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Decrease of magnetocaloric effect and magnetic susceptibility of ferromagnet due to magnetostructural phase transition

L'vov VA, Kosogor A.
europepmc   +1 more source

Development and Validation of the ClimHealth-K: A Scale for Assessing Perceived Knowledge and Awareness of Climate Change-Related Health Effects. [PDF]

Nurs Health Sci
Ülger TG, Gençer Şendur E, Tunçer E, Çelik İ, Bektaş M.   +4 more
europepmc   +1 more source