Results 91 to 100 of about 1,634,486 (241)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

SSTGCNs: Spectral–Spatial–Temporal Long-Range Dependencies Joint Feature Extraction With Graph Convolutional Networks for Adaptive Change Detection

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Hyperspectral image change detection plays an important role in ground observation tasks, making full use of the rich spectral and spatial information in the bitemporal hyperspectral to identify subtle changes in the surface.
Zhanyuan Chang, Yuwen Wei, Jie Lian, Mingxiao Jin, Dong Wang, Xuyang Li   +5 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

LULC change detection and future LULC modelling using RF and MLPNN-Markov algorithms in the uMngeni catchment, KwaZulu-Natal, South Africa

Frontiers in Environmental Science
Water catchment areas are the key strategic water sources with a variety of ecological benefits. However, the trajectory of Land Cover and Land Use Changes (LULC-C change poses a significant threat to water catchment areas, negatively affecting water ...
Orlando Bhungeni, Michael Gebreslasie, Ashadevi Ramjatan   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Advancing Self-Supervised Learning for Building Change Detection and Damage Assessment: Unified Denoising Autoencoder and Contrastive Learning Framework

Remote Sensing
Building change detection and building damage assessment are two essential tasks in post-disaster analysis. Building change detection focuses on identifying changed building areas between bi-temporal images, while building damage assessment involves ...
Songxi Yang, Bo Peng, Tang Sui, Meiliu Wu, Qunying Huang   +4 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Three-Dimensional Multitemporal Game Engine Visualizations for Watershed Analysis, Lighting Simulation, and Change Detection in Built Environments

ISPRS International Journal of Geo-Information
This study explores the reuse of high-resolution 3D spatial datasets for multiple urban analyses within a game engine environment, aligning with circular economy principles in sustainable urban planning. The work is situated in two residential test areas
Heikki Kauhanen, Toni Rantanen, Petri Rönnholm, Osama Bin Shafaat, Kaisa Jaalama, Arttu Julin, Matti Vaaja   +6 more
doaj   +1 more source

Detect Changes Like Humans: Incorporating Semantic Priors for Improved Change Detection

IEEE Transactions on Geoscience and Remote Sensing
25-09 accepted by IEEE ...
Yuhang Gan, Wenjie Xuan, Zhiming Luo, Lei Fang, Zengmao Wang, Juhua Liu, Bo Du   +6 more
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source