Results 111 to 120 of about 3,908,888 (282)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

LULC change detection and future LULC modelling using RF and MLPNN-Markov algorithms in the uMngeni catchment, KwaZulu-Natal, South Africa

Frontiers in Environmental Science
Water catchment areas are the key strategic water sources with a variety of ecological benefits. However, the trajectory of Land Cover and Land Use Changes (LULC-C change poses a significant threat to water catchment areas, negatively affecting water ...
Orlando Bhungeni, Michael Gebreslasie, Ashadevi Ramjatan   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Advancing Self-Supervised Learning for Building Change Detection and Damage Assessment: Unified Denoising Autoencoder and Contrastive Learning Framework

Remote Sensing
Building change detection and building damage assessment are two essential tasks in post-disaster analysis. Building change detection focuses on identifying changed building areas between bi-temporal images, while building damage assessment involves ...
Songxi Yang, Bo Peng, Tang Sui, Meiliu Wu, Qunying Huang   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Three-Dimensional Multitemporal Game Engine Visualizations for Watershed Analysis, Lighting Simulation, and Change Detection in Built Environments

ISPRS International Journal of Geo-Information
This study explores the reuse of high-resolution 3D spatial datasets for multiple urban analyses within a game engine environment, aligning with circular economy principles in sustainable urban planning. The work is situated in two residential test areas
Heikki Kauhanen, Toni Rantanen, Petri Rönnholm, Osama Bin Shafaat, Kaisa Jaalama, Arttu Julin, Matti Vaaja   +6 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Detect Changes Like Humans: Incorporating Semantic Priors for Improved Change Detection

IEEE Transactions on Geoscience and Remote Sensing
25-09 accepted by IEEE ...
Yuhang Gan, Wenjie Xuan, Zhiming Luo, Lei Fang, Zengmao Wang, Juhua Liu, Bo Du   +6 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source