Results 91 to 100 of about 21,460,949 (310)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Dual-Branch Seasonal Error Elimination Change Detection Framework Using Target Image Feature Fusion Generator

Remote Sensing
In change detection tasks, seasonal variations in spectral characteristics and surface cover can negatively impact performance when comparing image pairs from different seasons.
Hongming Zhu, Jipeng Zhang, Zeju Wang, Xinyu Liu, Qin Liu, Bowen Du   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Rapid Fine-Grained Damage Assessment of Buildings on a Large Scale: A Case Study of the February 2023 Earthquake in Turkey

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
High-resolution stereo satellite images (HRSSIs) have the potential to provide the accurate height and volume information, playing a crucial role in assessing building collapses during various natural disasters.
Zhonghua Hong, Hongyang Zhang, Xiaohua Tong, Shijie Liu, Ruyan Zhou, Haiyan Pan, Yun Zhang, Yanling Han, Jing Wang, Shuhu Yang   +9 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Extraction of Building Construction Time Using the LandTrendr Model With Monthly Landsat Time Series Data

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Extracting building construction time is crucial for effective land resource management and sustainable urban development, particularly in fast-growing urban areas.
Tengyun Hu, Meng Zhang, Xuecao Li, Tinghai Wu, Qiwei Ma, Jianneng Xiao, Xieqin Huang, Jinchen Guo, Yangchun Li, Donglie Liu   +9 more
doaj   +1 more source

Line-Constrained Shape Feature for Building Change Detection in VHR Remote Sensing Imagery

ISPRS International Journal of Geo-Information, 2018
Buildings represent the most relevant features of human activity in urban regions, but their change detection using very-high-resolution (VHR) remote sensing imagery is still a major challenge. Effective representation of the building is the key point in
Haifei Liu, Minhua Yang, Jie Chen, Jialiang Hou, Min Deng   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

High-Precision Heterogeneous Satellite Image Manipulation Localization: Feature Point Rules and Semantic Similarity Measurement

Remote Sensing
Misusing image tampering software makes it easier to manipulate satellite images, leading to a crisis of trust and security concerns in society. This study compares the inconsistencies between heterogeneous images to locate tampered areas and proposes a ...
Ruijie Wu, Wei Guo, Yi Liu, Chenhao Sun
doaj   +1 more source