Results 101 to 110 of about 169,052,029 (285)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

A Report by the Climate Change Science Program and the Subcommittee on Global Change Research [PDF]

, 2003
This strategic plan has been prepared by the 13 federal agencies participating in the CCSP, with coordination by the CCSP staff under the leadership of Dr. Richard H. Moss.
Climate Change Science Program and the Subcommittee on Global Change Research
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Comparative Analysis of Speed-Power Performance and Sport-Specific Skills Among Elite Youth Soccer Players with Different Start Procedures

Sports
Accurate interpretation of physical test results is essential to objectively measure parameters both at a single point in time and throughout longitudinal assessments.
Eduard Bezuglov, Anton Emanov, Timur Vakhidov, Elizaveta Kapralova, Georgiy Malyakin, Vyacheslav Kolesnichenko, Zbigniew Waśkiewicz, Larisa Smekalkina, Mikhail Vinogradov   +8 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Enhancing climate change communication: Strategies for profiling and targeting Australian interpretive communities

, 2013
This research aimed to provide practical information about how to design communications on climate change adaptation and target these to the Australian population.
Reser, Joseph, Hine, Donald, Hine, Donald W, Phillips, Wendy J, Ellul, Michelle, Reser, Joseph P, Watt, Susan, Cooksey, Ray W, Marks, Anthony, Nunn, Patrick, Watt, Susan E, Phillips, Wendy, Cooksey, Ray   +12 more
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Pairwise Comparison of Effects of Linear vs. Change of Direction Short Bout Sprint Intervals on Physical Performance of Youth Male Soccer Players

Sports
Our study aimed to examine and compare the effects of 12-week repeated sprint intervals with change of direction and linear sprint intervals on physical performance in young soccer players.
Peter Sagat
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Direction-led temporal control and expertise-based load redistribution in 45° cutting: an SPM-based analysis of ankle mechanics

Frontiers in Bioengineering and Biotechnology
Rapid change-of-direction movements are essential in basketball and other multidirectional sports and impose substantial mechanical demands on the ankle.
Xiao-shan Lei, Xiao-long Liao, Yilin Wang, Yun-chao Ma, Hao Lei   +4 more
doaj   +1 more source