Results 161 to 170 of about 10,645,086 (283)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Software belief reliability growth model incorporating change point and imperfect debugging based on uncertain differential equation approach. [PDF]

Sci Rep
Sharma N, Kumar V, Khan AA, Johri P, Ali F, AlZubi AA.   +5 more
europepmc   +1 more source

Efficient Multi-Change Point Analysis to Decode Economic Crisis Information from the S&P500 Mean Market Correlation. [PDF]

Entropy (Basel), 2023
Heßler M, Wand T, Kamps O.
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Multiple change point analysis and time series forecast of brucellosis reports in Xinjiang, China from 2010 to 2024. [PDF]

BMC Public Health
Yang L, Zhang W, Wang C, Ma J, Huang Y, Yao Y, Wang K.   +6 more
europepmc   +1 more source

Tracing Cognitive Processes in Insight Problem Solving: Using GAMs and Change Point Analysis to Uncover Restructuring. [PDF]

J Intell, 2023
Graf M, Danek AH, Vaci N, Bilalić M.
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Impact of Compensation Coefficients on Active Sequential Change-Point Detection. [PDF]

Seq Anal
Xu Q, Mei Y, Shi J.
europepmc   +1 more source

A change-point regression approach for estimating no observed adverse effect level from systematic review. [PDF]

J Clin Biochem Nutr, 2023
Kuramochi Y, Hayamizu K.
europepmc   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source