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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Restarted Bayesian Online Change-point Detector achieves Optimal Detection Delay
, 2020 Réda Alami +2 more
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Multiscale Change Point Detection
Theory of Probability & Its Applications, 2017zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Suvorikova, A., Spokoiny, V.
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2021
In situ TEM and other dynamic imaging instruments alter the landscape of materials science and engineering. The unique and unprecedented ability to observe the transformation of nanoscale objects as it occurs is unparalleled in comparison to other material characterization methods, and is of tremendous value to material scientists and engineers who ...
Chiwoo Park, Yu Ding
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In situ TEM and other dynamic imaging instruments alter the landscape of materials science and engineering. The unique and unprecedented ability to observe the transformation of nanoscale objects as it occurs is unparalleled in comparison to other material characterization methods, and is of tremendous value to material scientists and engineers who ...
Chiwoo Park, Yu Ding
openaire +1 more source
Change-points for point processes
2018This chapter studies estimation and testing methods for the intensities of parametric or functional Poisson models, for parametric or nonparametric hazard function under right-censoring and for point processes, with change-points at unknown time thresholds.
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Biometrika, 1987
The problem is that of testing for a change of the mean in a sequence of independent normal random variables with the same variance. Well-known tests such as likelihood ratio tests, tests based upon cusums of recursive residuals, Pettitt's test and the Chernoff-Zacks' statistic are investigated again through their approximate power.
James, Barry +2 more
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The problem is that of testing for a change of the mean in a sequence of independent normal random variables with the same variance. Well-known tests such as likelihood ratio tests, tests based upon cusums of recursive residuals, Pettitt's test and the Chernoff-Zacks' statistic are investigated again through their approximate power.
James, Barry +2 more
openaire +2 more sources
Smooth random change point models
Statistics in Medicine, 2010AbstractChange point models are used to describe processes over time that show a change in direction. An example of such a process is cognitive ability, where a decline a few years before death is sometimes observed. A broken‐stick model consists of two linear parts and a breakpoint where the two lines intersect. Alternatively, models can be formulated
Van Den Hout, Ardo +2 more
openaire +3 more sources
1993
The main objective of this paper is to survey procedures that one connected with the change point problem and with testing the constancy of regression relationship over a time. We will focus on the case of independent observations. Detailed algorithms are presented for most of the discussed methods.
Jaromír Antoch, Marie Hušková
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The main objective of this paper is to survey procedures that one connected with the change point problem and with testing the constancy of regression relationship over a time. We will focus on the case of independent observations. Detailed algorithms are presented for most of the discussed methods.
Jaromír Antoch, Marie Hušková
openaire +1 more source