Results 161 to 170 of about 961,218 (296)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Change Point Detection in Radar Reflectivity Measurements Contaminated by Speckle Noise

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
This article studies the use of airborne global navigation satellite system reflectometry techniques for remote sensing applications at regional scale.
Sarah El Hajj Chehade, Hamza Issa, Georges Stienne, Serge Reboul   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

A Multiple change-point detection framework on linguistic characteristics of real versus fake news articles. [PDF]

Sci Rep, 2023
Petrou N, Christodoulou C, Anastasiou A, Pallis G, Dikaiakos MD.   +4 more
europepmc   +1 more source

Algebraic change-point detection

Elementary techniques from operational calculus, differential algebra, and noncommutative algebra lead to a new approach for change-point detection, which is an important field of investigation in various areas of applied sciences and engineering ...
Michel Fliess, Cédric Join, Mamadou Mboup   +2 more
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

CINNAMON: A hybrid approach to change point detection and parameter estimation in single-particle tracking data

JPhys Photonics
Change point detection has become an important part of the analysis of the single-particle tracking (SPT) data, as it allows one to identify moments, in which the motion patterns of observed particles undergo significant changes.
Jakub Malinowski, Marcin Kostrzewa, Michał Balcerek, Weronika Tomczuk, Janusz Szwabiński   +4 more
doaj   +1 more source

Efficient multiple change point detection for high-dimensional generalized linear models. [PDF]

Can J Stat, 2023
Wang X, Liu B, Zhang X, Liu Y, Alzheimer’s Disease Neuroimaging Initiative.   +4 more
europepmc   +1 more source