Results 201 to 210 of about 233,902 (342)

An archaeological and archaeoseismological perspective on earthquakes in the coastal cities of Western Anatolia in the 3rd millennium BCE: Settlement abandonment and changes in social structures

Ümit Gündoğan
openalex   +1 more source

A Veteran Welfare State: Veterans' Benefits, Coalition Politics, and Social Policy Change, 1943-1973

, 2021
Melinda R. Tarsi
openalex   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Mental Health and the Climate Crisis: A Call to Action for Canadian Psychiatrists. [PDF]

Can J Psychiatry, 2023
Rosenbaum D, Levitt S.
europepmc   +1 more source

Food for Cities. What roles for local governments in the Global South? [PDF]

, 2017
Bricas, Nicolas, Fages, Roxane
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Climate change by any other name: Social representations and language practices of coastal inhabitants on Mayotte Island in the Indian Ocean. [PDF]

Public Underst Sci
Mori M, Longépée E, Lefer-Sauvage G, Banos A, Becu N, Charpentier P, Claverie T, Jeanson M, Le Duff M, Provitolo D, Stoica G.   +10 more
europepmc   +1 more source

Living in a Runaway World: Modern Change and the Limits of Social Control in Indian Society

Dheeraj Pratap Adhikari
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Japanese Love Hotels: Legal Change, Social Change, and Industry Change

, 2003
Mark D. West
openalex   +1 more source