Results 231 to 240 of about 22,201,636 (348)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Châtelperronian cultural diversity at its western limits: Shell beads and pigments from La Roche-à-Pierrot, Saint-Césaire. [PDF]

Proc Natl Acad Sci U S A
Bachellerie F, Gravina B, Rigaud S, Dayet L, Thomas M, Lebreton L, Morin E, Lesage C, Falguères C, Bard E, Bahain JJ, Baillet M, Beauval C, Bordes JG, Culioli G, Devièse T, Flas D, Garbé L, Guérin G, Lacrampe-Cuyaubère F, Lahaye C, Mallol C, Marot J, Maureille B, Michel A, Muth X, Regniers O, Tartar E, Teyssandier N, Thibeault A, Todisco D, Tombret O, Rougier H, Crevecoeur I.   +33 more
europepmc   +1 more source

Sport et changement social

, 1995
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The Perceived Role of Occupational Therapists in Climate Change. [PDF]

Can J Occup Ther
Du J, Bird A, Boniface G, Boniface J, Mortenson WB.   +4 more
europepmc   +1 more source

Collective memory and autobiography: Annie Ernaux’s Les Années [PDF]

, 2009
Reid, V.
core  

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Bridging Science and Subjectivity: Evolving Evidence, Emerging Technologies and the Call for Personalised Psychotherapy: Créer une passerelle entre la science et la subjectivité : Évolution des données probantes, arrivée de nouvelles technologies et appel à une psychothérapie personnalisée. [PDF]

Can J Psychiatry
Khan N.
europepmc   +1 more source