Results 71 to 80 of about 177,628,905 (262)

Challenges Associated with Colorectal Cancer in Pregnancy

Case Reports in Gastroenterology, 2019
Colorectal cancer is epidemiologically a disease of the middle-aged and elderly. However, it may occur in the young where it presents with virulent biological behavior and poor prognosis.
J.M.V. Amarjothi, Villalan Ramasamy, G.R. Senthil Kumaran, O.L. Naganath Babu   +3 more
doaj   +1 more source

Priming and the reliability of subjective well-being measures [PDF]

, 2010
Economists and behavioural scientists are beginning to make extensive use of measures of subjective well-being, and such data are potentially of value to policy-makers.
Dobson, Alexander, Proto, Eugenio, Oswald, Andrew J., Sgroi, Daniel   +3 more
core  

Well-being

, 2023
Mean personal well-being index (PWI) and national well-being index (NWI) scores for Statistical Area 2 (2018) units. Original data sourced from Census 2018 and New Zealand Attitudes and Values Study 2018.
Jesse Wiki (11444635)
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Involving children with intellectual disability in child well-being research : an inclusive methodological approach

, 2019
Despite the increasing body of research on children’s perspectives on well-being, few studies have included children with disability (1). This lacuna in child well-being literature has significant theoretical, methodological and policy implications.
Mogensen, Lise L. (R12298)
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Controversias actuales para definir las alteraciones del bienestar fetal

Medisan
Como propuesta de diferentes sociedades científicas se estableció el término estado fetal no tranquilizador en sustitución de sufrimiento fetal, que era considerado inespecífico.
Danilo Nápoles Méndez
doaj  

Evaluating the responsiveness of the Warwick Edinburgh Mental Well-Being Scale (WEMWBS) : group and individual level analysis [PDF]

, 2012
Background: Mental well-being now features prominently in UK and international health policy. However, progress has been hampered by lack of valid measures that are responsive to change.
Maheswaran, H., John Powell, Weich Scott, Powell, J. (John), Powell, John, Maheswaran Hendramoorthy, Weich, S., Sarah Stewart-Brown, Hendramoorthy Maheswaran, Stewart-Brown Sarah, Stewart-Brown, Sarah, Powell John, Scott Weich, Powell, J., Stewart-Brown, S., Maheswaran, Hendramoorthy, Weich, Scott, Stewart-Brown, Sarah L.   +17 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source