Results 91 to 100 of about 177,628,905 (262)

Maternal serum iron status during 1st trimester and maternal/fetal outcome [PDF]

Al-Azhar International Medical Journal
Background: In pregnancy, iron deficiency anemia—a widespread micronutrient deficiency—is linked to adverse outcomes including impaired immune function, preterm birth, and fetal mortality.
Wael Soliman Taha, Muhamed Ahmed Abdelmoaty, Omar Ahmed Abd Elghany Sakr   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

2017 Well Being Trust Annual Report

, 2018
Tyler Norris, writing in the 2017 Well Being Trust Annual Report: This is a promising moment for our nation, as the importance of mental health and well-being become obvious to growing numbers of Americans and awareness of mental health disorders ...
Well Being Trust
core   +1 more source

STEREOLOGICAL STUDIES ON FETAL VASCULAR DEVELOPMENT IN HUMAN PLACENTAL VILLI

Image Analysis and Stereology, 2011
In human pregnancy, fetal well-being depends on the development of placental villi and the creation and maintenance of fetal microvessels within them.
Terry M Mayhew
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

How Political Systems and Social Welfare Policies Affect Well-being

, 2018
This chapter focusses on the question of how formal institutions, like those governing the level of freedom and the generosity of the welfare state, affect self-reported well-being.
MacCulloch, Robert
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Plasma Cell Alloantigen 1 and IL-10 Secretion Define Two Distinct Peritoneal B1a B Cell Subsets With Opposite Functions, PC1high Cells Being Protective and PC1low Cells Harmful for the Growing Fetus

Frontiers in Immunology, 2018
B cells possess various immuno regulatory functions. However, research about their participation in tolerance induction toward the fetus is just emerging.
Anne Schumacher, Stefanie Ehrentraut, Markus Scharm, Hongsheng Wang, Roland Hartig, Herbert C. Morse, Ana Claudia Zenclussen   +6 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

The effects of Iranian traditional music on cervical dilation and labor progress in the active stage of term pregnancy: A nonrandomized controlled trial

Health Science Reports
Background and Aims Childbirth is a multifaceted and distressing event that can profoundly affect mothers' psychological and physical well‐being. Noninvasive interventions like music therapy have been explored to improve labor outcomes by decreasing pain
Athar Rasekh Jahromi, Vahid Rahmanian, Fatemeh Kiani, Asra Ansari, Nikta Taghipour   +4 more
doaj   +1 more source