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Paroxysmal extreme pain disorder (PEPD), previously known as familial rectal pain (FRP, OMIM 167400), is an inherited disease causing intense burning rectal, ocular, and submandibular pain and flushing. Fertleman et al. (this issue of Neuron) show that mutations in SCN9A, the gene encoding the sodium channel Na(V)1.7 channels, are responsible for this ...
Catterall, William A., Yu, Frank H.
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El cambio climático está intensificando la pérdida de glaciares en el Perú, lo que afecta de manera directa la calidad y disponibilidad del agua en las zonas altoandinas.
Channel Yurico Rodriguez-Torres
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The excitability of neurons is tightly dependent on their ion channel repertoire. Among these channels, the leak sodium channel NALCN plays a crucial role in the maintenance of the resting membrane potential.
Malik Bouasse +4 more
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Bounds on the Per-Sample Capacity of Zero-Dispersion Simplified Fiber-Optical Channel Models [PDF]
A number of simplified models, based on perturbation theory, have been proposed for the fiber-optical channel and have been extensively used in the literature. Although these models are mainly developed for the low-power regime, they are used at moderate
Agrell, Erik +2 more
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We present an algorithm that, given a channel, determines if there is a distance for it such that the maximum likelihood decoder coincides with the minimum distance decoder. We also show that any metric, up to a decoding equivalence, can be isometrically embedded into the hypercube with the Hamming metric, and thus, in terms of decoding, the Hamming ...
D'Oliveira, Rafael G. L., Firer, Marcelo
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Activation of TMEM16A Ca2+-activated Cl− channels by ROCK1/moesin promotes breast cancer metastasis
Introduction: Transmembrane protein 16A (TMEM16A) is a Ca2+-activated chloride channel that plays a role in cancer cell proliferation, migration, invasion, and metastasis.
Shuya Luo +13 more
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Capacity of a POST Channel with and without Feedback
We consider finite state channels where the state of the channel is its previous output. We refer to these as POST (Previous Output is the STate) channels. We first focus on POST($\alpha$) channels.
Asnani, Himanshu +2 more
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Detection of fishing pressure using ecological network indicators derived from ecosystem models
Marine ecosystems are exposed to multiple stressors, mainly fisheries that, whenever mismanaged, may cause irreversible damages to whole food webs. Ecosystem models have been applied to forecast fisheries impact on fish stocks and marine food webs. These
Maysa Ito +4 more
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We determine, for the first time, the requirement on channel reciprocity to activate uplink channel training, instead of downlink channel training, to achieve a higher data rate for the downlink transmission from a multi-antenna base station to a single ...
Li, Chunhui, Yan, Shihao, Yang, Nan
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A novel model of third phase inclusions on two phase boundaries
A new computationally efficient model of an included phase located at the interface between two other phases is developed by projecting the boundaries of the inclusion onto the boundary between the two other phases.
Andrew A. Prudil, Michael J. Welland
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