Results 81 to 90 of about 4,718,784 (295)

Automatic Detection and Classification of Hypertensive Retinopathy with Improved Convolution Neural Network and Improved SVM

Bioengineering
Hypertensive retinopathy (HR) results from the microvascular retinal changes triggered by hypertension, which is the most common leading cause of preventable blindness worldwide.
Usharani Bhimavarapu, Nalini Chintalapudi, Gopi Battineni   +2 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Motor Bearing Fault Diagnosis Based on Current Signal Using Time–Frequency Channel Attention

World Electric Vehicle Journal
As they are the core components of the drive motor in electric vehicles, the accurate fault diagnosis of rolling bearings is the key to ensuring the safe operation of electric vehicles. At present, intelligent diagnostic methods based on current signals (
Zhiqiang Wang, Chao Guan, Shangru Shi, Guozheng Zhang, Xin Gu   +4 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Covert Visual Spatial Attention: Effects Of Voluntary And Involuntary Attention On Channel Enhancement And Channel Selection [PDF]

, 2014
The ability to fixate ones eyes on one object while attending to another object is known as covert visual attention. The present study investigated the effects of covert visual attention on reaction time (RT) and accuracy while manipulating cue types (i.
Luna, Rocio
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Multi-Channel Retail Supply Chain Management: Fulfillment systems in Multi-Channel Retailing - Customer Expectations and Economic Performance [PDF]

Increasingly, store-based retailers are opening an additional online sales channel and becoming multi-channel retailers. The integration of these different channels raises the question how to redefine the strategic marketing elements and the operations ...
Gerald Lang
core  

A Latency-Efficient Integration of Channel Attention for ConvNets

Computers, Materials & Continua
Designing fast and accurate neural networks is becoming essential in various vision tasks. Recently, the use of attention mechanisms has increased, aimed at enhancing the vision task performance by selectively focusing on relevant parts of the input. In this paper, we concentrate on squeeze-and-excitation (SE)-based channel attention, considering the ...
Park, Woongkyu, Choi, Yeongyu, Mekala, Mahammad Shareef, SangChoi, Gyu, Yoo, Kook-Yeol, Jung, Ho-youl   +5 more
openaire   +3 more sources