Results 81 to 90 of about 4,485,063 (290)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Motor Bearing Fault Diagnosis Based on Current Signal Using Time–Frequency Channel Attention

World Electric Vehicle Journal
As they are the core components of the drive motor in electric vehicles, the accurate fault diagnosis of rolling bearings is the key to ensuring the safe operation of electric vehicles. At present, intelligent diagnostic methods based on current signals (
Zhiqiang Wang, Chao Guan, Shangru Shi, Guozheng Zhang, Xin Gu   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

An investigation into history documentary production processes, How Britain Bridges the World, 60 minute documentary, The History Channel

, 2010
An investigation into history documentary production processes - How Britain Bridges the World - 60 minute documentary - The History Channel The documentary narrative and content was developed by Senior Lecturer Fiona Graham and explored the engineering
Title Role Productions, Manchester, GRAHAM, Fiona, History Channel   +2 more
core   +5 more sources

Multi-Channel Retail Supply Chain Management: Fulfillment systems in Multi-Channel Retailing - Customer Expectations and Economic Performance [PDF]

Increasingly, store-based retailers are opening an additional online sales channel and becoming multi-channel retailers. The integration of these different channels raises the question how to redefine the strategic marketing elements and the operations ...
Gerald Lang
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Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

A Latency-Efficient Integration of Channel Attention for ConvNets

Computers, Materials & Continua
Designing fast and accurate neural networks is becoming essential in various vision tasks. Recently, the use of attention mechanisms has increased, aimed at enhancing the vision task performance by selectively focusing on relevant parts of the input. In this paper, we concentrate on squeeze-and-excitation (SE)-based channel attention, considering the ...
Park, Woongkyu, Choi, Yeongyu, Mekala, Mahammad Shareef, SangChoi, Gyu, Yoo, Kook-Yeol, Jung, Ho-youl   +5 more
openaire   +3 more sources

Channel 40 news segment on E. Coli rapid detection method (April 1998)

, 1998
This is a short Channel 40 news segment on Dr. Chun-Kwun Wun and Dr. Frank J. Torre development of a E. Coli Rapid Detection method. The segment is about two minutes and 20 seconds long. The segment was digitized from a VHS tape which over the years seem
ABC Channel 40;
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