Results 91 to 100 of about 318,902 (264)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Design of Dual-Band MIMO Array Antenna and Its Characterization for Urban Millimeter Wave Channel Conditions

open access: yesIEEE Access
The multiple-input-multiple-output (MIMO) antenna improves the channel capacity, and the array antenna improves the channel condition. A combined feature benefits the current cellular and other 5G applications.
B. G. Parveez Shariff   +8 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Channel Capacity Analysis of Spread Spectrum Watermarking in Radio Frequency Signals

open access: yesIEEE Access, 2017
The carrier of the digital watermark expands from audio signals to radio frequency (RF) signals. Unlike audio signals, RF signals, such as the watermark transmission carrier, must be correctly demodulated with the watermark signals so that the distortion
Xu Xie, Zhengguang Xu, Hui Xie
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Novel half-duplex relay strategy and its resource allocation

open access: yesTongxin xuebao, 2009
Conventional time-division half-duplex relay strategies based on amplify-and-forward or decode-and-forward strategy could relieve relay nodes from full-duplex requirement but lead to degraded spectrum efficiency.
LI Yong   +3 more
doaj  

Continuity of Channel Parameters and Operations under Various DMC Topologies

open access: yesEntropy, 2018
We study the continuity of many channel parameters and operations under various topologies on the space of equivalent discrete memoryless channels (DMC).
Rajai Nasser
doaj   +1 more source

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