Results 71 to 80 of about 338,609 (215)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Novel half-duplex relay strategy and its resource allocation

open access: yesTongxin xuebao, 2009
Conventional time-division half-duplex relay strategies based on amplify-and-forward or decode-and-forward strategy could relieve relay nodes from full-duplex requirement but lead to degraded spectrum efficiency.
LI Yong   +3 more
doaj  

Channel Capacity Analysis of Spread Spectrum Watermarking in Radio Frequency Signals

open access: yesIEEE Access, 2017
The carrier of the digital watermark expands from audio signals to radio frequency (RF) signals. Unlike audio signals, RF signals, such as the watermark transmission carrier, must be correctly demodulated with the watermark signals so that the distortion
Xu Xie, Zhengguang Xu, Hui Xie
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Continuity of Channel Parameters and Operations under Various DMC Topologies

open access: yesEntropy, 2018
We study the continuity of many channel parameters and operations under various topologies on the space of equivalent discrete memoryless channels (DMC).
Rajai Nasser
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Characterization of Narrowband Noise and Channel Capacity for Powerline Communication in France

open access: yesEnergies, 2018
Narrowband powerline communication (NB-PLC) systems represent a key step for the real development of smart grids’ applications in the medium voltage (MV) and low voltage (LV) networks.
Imène Elfeki   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

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