Results 71 to 80 of about 2,741,134 (340)

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Neural Models of Temporally Organized Behaviors: Handwriting Production and Working Memory [PDF]

, 1994
Advanced Research Projects Agency (ONR N00014-92-J-4015); Office of Naval Research (N00014-91-J-4100, N00014-92-J ...
Grossberg, Stephen
core   +1 more source

The future prospects of muon colliders and neutrino factories

, 2019
The potential of muon beams for high energy physics applications is described along with the challenges of producing high quality muon beams. Two proposed approaches for delivering high intensity muon beams, a proton driver source and a positron driver ...
Boscolo, Manuela, Delahaye, Jean Pierre, Palmer, Mark   +2 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Connecting Territorial Knowledge Arenas – the Interrelationship between CEMAT and EU Activities in Spatial Development Policy

European Journal of Spatial Development, 2012
Against the background of the increasing importance of evidence, knowledge and learning in both domestic and transnational policy development processes, this paper analyses how non-EU and intra-European Union knowledge arenas in spatial development ...
Matti Fritsch
doaj   +3 more sources

Unravelling the spatiotemporal trade-offs and synergies among hydrological ecosystem services in a large floodplain lake

Ecological Indicators
Understanding the dynamics of ecosystem services (ESs) and their interactions is vital for effective environmental management. This knowledge remains limited in highly dynamic systems, however, particularly floodplain lakes. In this study, spatiotemporal
Bing Li, Guishan Yang, Rongrong Wan, David P. Hamilton, Xueran Wang   +4 more
doaj   +1 more source

On the Lightweight Potential of Laser Additive Manufactured NiTi Triply Periodic Minimal Sheet Lattices

Advanced Engineering Materials, EarlyView.
This study explores the lightweight potential of laser additive‐manufactured NiTi triply periodic minimal surface sheet lattices. It systematically investigates the effects of relative density and unit cell size on surface quality, deformation recovery, compression behavior, and energy absorption.
Haoming Mo, Shuo Qu, Shiming Gao, Xu Song   +3 more
wiley   +1 more source

Enhancing the hierarchy and octant sensitivity of ESSνSB in conjunction with T2K, NOνA and ICAL@INO

Journal of High Energy Physics, 2019
The main aim of the ESSνSB proposal is the discovery of the leptonic CP phase δ CP with a high significance (5σ for 50% values of δ CP) by utilizing the physics at the second oscillation maxima of the P μe channel.
Kaustav Chakraborty, Srubabati Goswami, Chandan Gupta, Tarak Thakore   +3 more
doaj   +1 more source