Results 61 to 70 of about 2,741,134 (340)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Co-located wave and offshore wind farms: A preliminary approach to the shadow effect [PDF]
, 2014 In recent years, with the consolidation of offshore wind technology and the progress carried out for wave energy technology, the option of combine both technologies has arisen.
Abanades, J +4 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Lightweight Joint Simulation of Vehicular Mobility and Communication with LIMoSim
, 2017 The provision of reliable and efficient communication is a key requirement for the deployment of autonomous cars as well as for future Intelligent Transportation Systems (ITSs) in smart cities.
Eckermann, Fabian +5 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Applied Sciences, 2021 Thermal energy storage systems open up high potentials for improvements in efficiency and flexibility for power plant and industrial applications. Transferring such technologies as basis for thermal management concepts in battery-electric vehicles allow ...
Volker Dreißigacker
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
PLoS ONEIn this study, we propose a new type of small-channel plug-in, the double S turbulators, for passive heat transfer enhancement to improve the flow and heat transfer performance of the fluid in the channel.
Yinhang Xi, Fanmao Meng
doaj +1 more source
Synergies between app-based car-related shared mobility services for the development of more profitable business models [PDF]
, 2019 Purpose: Emerging shared mobility services are an opportunity for cities to reduce the number of car single trips to both improve traffic congestion and the environment.
Gilibert Junyent, Mireia +1 more
core +4 more sources
Brg1 and RUNX1 synergy in regulating TRPM4 channel in mouse cardiomyocytes
Frontiers in PharmacologyBackgroundTransient Receptor Potential Melastatin 4 (TRPM4), a non-selective cation channel, plays a critical role in cardiac conduction abnormalities. Brg1, an ATP-dependent chromatin remodeler, is essential for regulating gene expression in both heart development and disease. Our previous studies demonstrated Brg1 impacted on cardiac sodium/potassium
Tao Ban +20 more
openaire +3 more sources