Results 131 to 140 of about 18,132 (269)
Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1
British Journal of Pharmacology, EarlyView.Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim +10 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.We report a triply responsive artificial ion channel, showing tuneable activity, and responsive to three distinct stimuli ‐ light, pH, and ligand – which we use to formulate an AND to OR switchable molecular logic gate. Abstract Ion channels are ubiquitous in Nature, performing complex and essential tasks in our bodies. Synthetic chemists have begun to
Javid Ahmad Malla +5 more
wiley +2 more sources
Neurotransmitters and Sodium Channelopathies; Possible Link?
Pediatric Neurology Briefs, 2017 Investigators from the University of British Columbia, Great Ormond Street Hospital for Children, and the National Hospital reported their findings on neurotransmitter deficiencies in two patients with mutations in voltage-gated sodium genes (SCN2A and ...
Michael F. Hammer +1 more
doaj +1 more source
Muscleblind-like 3 deficit results in a spectrum of age-associated pathologies observed in myotonic dystrophy. [PDF]
, 2016 Myotonic dystrophy type I (DM1) exhibits distinctive disease specific phenotypes and the accelerated onset of a spectrum of age-associated pathologies.
Abdallah, Walid F +9 more
core +1 more source
Developmental Medicine &Child Neurology, EarlyView.This multicenter retrospective study evaluated the use of intravenous immunoglobulin (IVIG) in 14 children with Dravet syndrome as a preventive strategy against febrile status epilepticus. Over a 6‐month period, IVIG was associated with a significant reduction in hospitalizations for febrile status epilepticus.
Romane Marc +9 more
wiley +1 more source
Decreased cardiac excitability secondary to reduction of sodium current may be a significant contributor to reduced contractility in a rat model of sepsis [PDF]
, 2014 Pembelajaran pada hakekatnya adalah proses interaksi antara peserta didik dengan lingkungannya. Pembelajaran merupakan aktualisasi kurikulum yang menuntut keaktifan guru dalam menciptakan dan menumbuhkan kegiatan peserta didik sesuai dengan rencana yang ...
Andrew Koesters +2 more
core +2 more sources
International Journal of Molecular Sciences, 2018 Stroke-like episodes (SLE) occur in phosphomannomutase deficiency (PMM2-CDG), and may complicate the course of channelopathies related to Familial Hemiplegic Migraine (FHM) caused by mutations in CACNA1A (encoding CaV2.1 channel).
Mercè Izquierdo-Serra +19 more
semanticscholar +1 more source
Epilepsia, EarlyView.Abstract Objective Conditions presenting with both epilepsy and movement disorders (EPIMDs) range from relatively benign cases to severe developmental encephalopathies. However, the full clinical and genetic spectrum still needs to be better defined.
Davide Caputo +15 more
wiley +1 more source
Autoimmune Calcium Channelopathies and Cardiac Electrical Abnormalities
Frontiers in Cardiovascular Medicine, 2019 Patients with autoimmune diseases are at increased risk for developing cardiovascular diseases, and abnormal electrocardiographic findings are common.
Yongxia Sarah Qu +7 more
doaj +1 more source
Huntington's Disease‐like Syndrome as a Rare Presentation of CACNA1A‐Related Disorder
Movement Disorders Clinical Practice, EarlyView.
Petros Boumis +14 more
wiley +1 more source