Results 151 to 160 of about 18,132 (269)

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

BK channel activity in skin fibroblasts from patients with neurological disorder

Channels
Seventy-five unique variants in the KCNMA1 gene have been identified from individuals with neurological disorders. However, variant pathogenicity and evidence for disease causality are lacking in most cases.
Ria L. Dinsdale, Thomas R. Middendorf, Deborah Disilvestre, David Adams, William Gahl, Ellen F. Macnamara, Lynne Wolfe, Camilo Toro, Cynthia J. Tifft, Andrea L. Meredith   +9 more
doaj   +1 more source

Structure-based assessment of disease-related mutations in human voltage-gated sodium channels

Protein & Cell, 2017
Voltage-gated sodium (Nav) channels are essential for the rapid upstroke of action potentials and the propagation of electrical signals in nerves and muscles. Defects of Nav channels are associated with a variety of channelopathies.
Weiyun Huang, Minhao Liu, S. Frank Yan, Nieng Yan   +3 more
doaj   +1 more source

Novel Echocardiographic Index for Risk Stratification of Ventricular Arrhythmias and Mortality Based on Right Ventricular Function

Journal of Arrhythmia, Volume 42, Issue 1, February 2026.
Patients undergoing ICD implantation with both preprocedural echocardiography and cardiac magnetic resonance (CMR) were retrospectively analyzed to assess right ventricular (RV) function. Echocardiographic RV fractional area change (RVFAC) and the contraction pressure index (CPI), as well as CMR‐derived RV ejection fraction (RVEF), predicted ...
Toshinori Chiba, Takatsugu Kajiyama, Yusuke Kondo, Hiroyuki Takaoka, Noriko Suzuki‐Eguchi, Masahiro Nakano, Miyo Nakano, Satoko Ryuzaki, Yukiko Takanashi, Yuya Komai, Yusei Nishikawa, Yoshio Kobayashi   +11 more
wiley   +1 more source

Predictors of Ventricular Abnormalities in Children with Idiopathic Ventricular Extrasystoles

Children
Background and Objectives: Ventricular extrasystoles, which are the most common arrhythmias in healthy children and adolescents, could be a reliable factor for the prognosis of structural heart diseases.
Rita Kunigeliene, Odeta Kinciniene, Germanas Marinskis, Vytautas Usonis   +3 more
doaj   +1 more source

ECG Markers of Positive Drug Challenge With Ajmaline in Patients With Brugada Syndrome

Annals of Noninvasive Electrocardiology, Volume 31, Issue 1, January 2026.
A prominent S‐wave in lead II on a nondiagnostic baseline ECG is a powerful predictor for unmasking Brugada syndrome during an ajmaline challenge. This subtle sign enhances patient selection for provocation testing and aids in risk stratification, particularly in familial screening.
Erol Tülümen, Mathieu Kruska, Sara Wuerfel, Maximilian Kohl, Volker Liebe, Ibrahim Akin, Juergen Kuschyk, Daniel Duerschmied, Martin Borggrefe, Boris Rudic   +9 more
wiley   +1 more source

Channelopathy of small- and intermediate-conductance Ca^2+-activated K^+ channels

Acta Pharmacologica Sinica, 2022
Y. Nam, Myles Downey, M. A. Rahman, Meng Cui, Miao Zhang   +4 more
semanticscholar   +1 more source

Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms

Cell Proliferation, Volume 59, Issue 1, January 2026.
Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng, Zuping Wu, Mengjie Wu, Liang Xie, Qianming Chen   +4 more
wiley   +1 more source

Understanding CPVT pathogenic mechanisms based on mutation location within RyR2: towards personalized medicine?

The Journal of Physiology, EarlyView.
Jean‐Pierre Benitah, Esther Zorio, Ana María Gómez   +2 more
wiley   +1 more source

Recovery from acidosis is a robust trigger for loss of force in murine hypokalemic periodic paralysis. [PDF]

, 2019
Periodic paralysis is an ion channelopathy of skeletal muscle in which recurrent episodes of weakness or paralysis are caused by sustained depolarization of the resting potential and thus reduction of fiber excitability.
Cannon, Stephen C, DiFranco, Marino, Mi, Wentao, Quinonez, Marbella, Wu, Fenfen   +4 more
core   +1 more source