Results 101 to 110 of about 18,335 (296)
Recent Developments in the Optical Control of Adrenergic Signaling
Medicinal Research Reviews, EarlyView.ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi +4 more
wiley +1 more source
Frontiers in Neural Circuits, 2013 Proper brain function relies on exquisite balance between excitation and inhibition, where inhibitory circuits play fundamental roles towards sculpting principle neuron output and information processing.
Longwen eHuang +3 more
doaj +1 more source
eLife, 2021 The crystal structure of the light-gated anion channel GtACR1 reported in our previous Research Article (Li et al., 2019) revealed a continuous tunnel traversing the protein from extracellular to intracellular pores.
Hai Li +8 more
doaj +1 more source
Encoding the Light-Sensitivity of Channelrhodopsin-2 [PDF]
Biophysical Journal, 2014 Microbial rhodopsins are routinely used as light-controlled switches in neurobiology. Their versatile applicability relies on the simplicity of the optogenetic approach. Light-sensitivity is promoted to the host cell encoded in genetic information.
Christian Bamann +2 more
openaire +2 more sources
Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light
Medicinal Research Reviews, EarlyView.ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva +5 more
wiley +1 more source
Optogenetic dissection of amygdala functioning
Frontiers in Behavioral Neuroscience, 2014 Studies of amygdala functioning have occupied a significant place in the history of understanding how the brain controls behavior and cognition. Early work on the amygdala placed this small structure as a key component in the regulation of emotion and ...
Ryan eLalumiere
doaj +1 more source
Root Mean Square Error of Neural Spike Train Sequence Matching with Optogenetics
, 2017 Optogenetics is an emerging field of neuroscience where neurons are genetically modified to express light-sensitive receptors that enable external control over when the neurons fire.
Eckford, Andrew W. +2 more
core +1 more source
Optical excitation and detection of neuronal activity [PDF]
, 2017 Optogenetics has emerged as an exciting tool for manipulating neural activity, which in turn, can modulate behavior in live organisms. However, detecting the response to the optical stimulation requires electrophysiology with physical contact or ...
Gillette, Martha +8 more
core +2 more sources
Crystal structure of the natural anion-conducting channelrhodopsin GtACR1
Nature, 2018 The naturally occurring channelrhodopsin variant anion channelrhodopsin-1 (ACR1), discovered in the cryptophyte algae Guillardia theta, exhibits large light-gated anion conductance and high anion selectivity when expressed in heterologous settings ...
Y. Kim +12 more
semanticscholar +1 more source
Functional investigation of the light-gated Channelrhodopsin [PDF]
Biophysical Journal, 2009 The retinal proteins Channelrhodopsin-1 and −2 (ChR-1 and −2) from Chlamydomonas reinhardtii, which were first described as light-gated ion channels by Nagel et al. in 2002 and 2003, emerged in the last few years as advantageous tools. Since they open up rapidly after absorption of a photon and permeate ions like sodium or calcium, Channelrhodopsins ...
Ernst Bamberg, Julia Spitz
openaire +2 more sources