Results 101 to 110 of about 18,484 (195)

Light and pH-induced Changes in Structure and Accessibility of Transmembrane Helix B and Its Immediate Environment in Channelrhodopsin-2 [PDF]

, 2016
A variant of the cation channel channelrhodopsin-2 from Chlamydomonas reinhardtii (CrChR2) was selectively labeled at position Cys-79 at the end of the first cytoplasmic loop and the beginning of transmembrane helix B with the fluorescent dye ...
Alexiev, Ulrike, Balke, Jens, Krause, Nils, Schlesinger, Ramona, Schneider, Constantin, Schneider, Franziska, Volz, Pierre, Walter, Maria   +7 more
core   +1 more source

Optoelectronic Interfaces for Nongenetic Modulation of Excitable Tissues

Small Methods, EarlyView.
This review summarizes recent advances in nongenetic optoelectronic technologies for the modulation of excitable biotissues, covering material selection, device design, and working principles, as well as characterization methods. Representative applications in in vitro and in vivo models of the cardiac, central, and peripheral nervous systems are ...
Qi Wang, Jinghua Li
wiley   +1 more source

Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior. [PDF]

, 2017
Functional imaging and gene expression studies both implicate the medial prefrontal cortex (mPFC), particularly deep-layer projection neurons, as a potential locus for autism pathology.
Brumback, AC, Davatolhagh, F, Ellwood, IT, Iafrati, J, Kjaerby, C, Lee, AT, Nagaraj, S, Patel, T, Robinson, S, Sohal, VS   +9 more
core   +1 more source

Repetitive Transcranial Magnetic Stimulation Induces Cognitive Recovery in Alzheimer's Disease via GABAergic Neuron Activation of the Cx3cl1‐Cx3cr1 Axis

Cell Proliferation, EarlyView.
Schematic diagram illustrating the molecular mechanisms of the Cx3cl1‐Cx3cr1 axis mediated by rTMS activation of GABAergic neurons in the process of cognitive function recovery in AD. ABSTRACT This study aimed to investigate the impact of repetitive transcranial magnetic stimulation (rTMS) on cognitive recovery in Alzheimer's disease (AD) by exploring ...
Yunxiao Kang, Jilun Liu, Yu Wang, Jiaying Wang, Jinyang Wang, Chenming Zhou, Rui Cui, Tianyun Zhang   +7 more
wiley   +1 more source

Sparsened neuronal activity in an optogenetically activated olfactory glomerulus [PDF]

, 2018
© The Author(s), 2018. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 8 (2018): 14955, doi:10.1038/s41598-018-33021-w.Glomeruli are the functional units ...
Bozza, Thomas, Braubach, Oliver R., Choi, Yunsook, Cohen, Lawrence B., Geiller, Tristan, Homma, Ryota, Tombaz, Tuce   +6 more
core   +2 more sources

Optogenetic stimulation of the median preoptic nucleus: Effects on hypothalamic paraventricular nucleus magnocellular neurons after chronic intermittent hypoxia exposure

Journal of Neuroendocrinology, EarlyView.
Abstract Median preoptic nucleus (MnPO) neurons projecting to the hypothalamic paraventricular nucleus (PVN) are linked to hypertension induced by chronic intermittent hypoxia (CIH), a model of obstructive sleep apnea. The modulation of MnPO‐driven synaptic activity in PVN magnocellular neurons (MNCs) by CIH remains unexamined.
Obed T. Paundralingga, Shuping Jia, George E. Farmer Jr, Glenn M. Toney, J. Thomas Cunningham   +4 more
wiley   +1 more source

Organic light-emitting diodes for optogenetic stimulation of Drosophila larvae [PDF]

, 2016
We are grateful for financial support from the Scottish Funding Council (through SUPA), Human Frontier Science Program (RGY0074/2013), Wellcome Trust Institutional Strategic Support Fund St Andrews, the RS Macdonald Charitable Trust, and EPSRC via grant ...
Gather, Malte Christian, Morton, Andrew, Murawski, Caroline, Pulver, Stefan, Samuel, Ifor David William   +4 more
core   +1 more source

Unifying photocycle model for light adaptation and temporal evolution of cation conductance in channelrhodopsin-2

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Understanding the mechanisms of photoactivated biological processes facilitates the development of new molecular tools, engineered for specific optogenetic applications, allowing the control of neuronal activity with light.
Jens Kuhne, J. Vierock, S. A. Tennigkeit, Max-Aylmer Dreier, Jonas Wietek, Dennis Petersen, Konstantin Gavriljuk, S. El-Mashtoly, P. Hegemann, K. Gerwert   +9 more
semanticscholar   +1 more source

Reciprocal connectivity between mitral cells and external plexiform layer interneurons in the mouse olfactory bulb.

Frontiers in Neural Circuits, 2013
Proper brain function relies on exquisite balance between excitation and inhibition, where inhibitory circuits play fundamental roles towards sculpting principle neuron output and information processing.
Longwen eHuang, Isabella eGarcia, Hsin-I eJen, Benjamin R. Arenkiel   +3 more
doaj   +1 more source

Models of cardiomyocyte–non‐myocyte electrical interactions

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiomyocyte–non‐myocyte (CM–NM) electrotonic coupling. Left: conceptual contact‐based interactions between CM and other NM via connexin (Cx) proteins. Three basic scenarios are proposed: (i) ‘zero‐sided coupling’ where there are no electrical connections between CM and NM, (ii) ‘single‐sided coupling’ where NM are connected to ...
Ana Simon‐Chica, Axel Loewe, Peter Kohl   +2 more
wiley   +1 more source