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Emerging optogenetics technologies in biomedical applications

open access: yesSmart Medicine, 2023
Optogenetics is a cutting‐edge technology that merges light control and genetics to achieve targeted control of tissue cells. Compared to traditional methods, optogenetics offers several advantages in terms of time and space precision, accuracy, and ...
Haozhen Ren   +4 more
doaj   +2 more sources

Optogenetics: Solving the Enigma of Sleep [PDF]

open access: yesSleep Medicine Research, 2018
Sleep is a crucial and evolutionarily conserved phenomenon, but the mechanisms that control sleep-wake behavior and underlie sleep disorders are not yet fully understood.
Victor James Drew, Jae Meen Lee, Tae Kim
doaj   +3 more sources

A bibliometric profile of optogenetics: quantitative and qualitative analyses [PDF]

open access: yesFrontiers in Neuroscience, 2023
IntroductionOptogenetics is a rapidly developing field combining optics and genetics, with promising applications in neuroscience and beyond.
Zhonghan Zhou   +20 more
doaj   +2 more sources

Dual-channel optogenetics in yeast for multiplexed light-based control of cellular processes and pathways [PDF]

open access: yesNature Communications
Optogenetics which involves the use of light to control cell functions on a genetic level has found utility in studying cell physiology, biomaterials and metabolic engineering. S. cerevisiae is an industrially relevant model organism that is used in many
Linus Yu Han Tan   +4 more
doaj   +2 more sources

Design of a palette of SNAP-tag mimics of fluorescent proteins and their use as cell reporters

open access: yesCell Discovery, 2023
Naturally occurring fluorescent proteins (FPs) are the most widely used tools for tracking cellular proteins and sensing cellular events. Here, we chemically evolved the self-labeling SNAP-tag into a palette of SNAP-tag mimics of fluorescent proteins ...
Dasheng Zhang   +20 more
doaj   +1 more source

Group-based, autonomous, individualized training and testing of long-tailed macaques (Macaca fascicularis) in their home enclosure to a visuo-acoustic discrimination task

open access: yesFrontiers in Psychology, 2022
In recent years, the utility and efficiency of automated procedures for cognitive assessment in psychology and neuroscience have been demonstrated in non-human primates (NHP).
Jorge Cabrera-Moreno   +13 more
doaj   +1 more source

Flexible auditory training, psychophysics, and enrichment of common marmosets with an automated, touchscreen-based system

open access: yesNature Communications, 2022
The authors present a cage-based stand-alone platform for autonomous, standardized, and unsupervised training and testing of visuo-auditory-cued behaviours of common marmosets. The experiments do not require dietary restriction or social separation.
A. Calapai   +3 more
doaj   +1 more source

Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors

open access: yesCell Regeneration, 2022
Cell metabolism plays vital roles in organismal development, but it has been much less studied than transcriptional and epigenetic control of developmental programs.
Ting Li   +5 more
doaj   +1 more source

A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice

open access: yesNature Communications, 2021
Pulsing cellular dynamics in genetic circuits have been shown to provide critical capabilities to cells in stress response, signaling and development.
Ting Li   +9 more
doaj   +1 more source

Advances in optogenetic studies of depressive-like behaviors and underlying neural circuit mechanisms

open access: yesFrontiers in Psychiatry, 2022
BackgroundsThe neural circuit mechanisms underlying depression remain unclear. Recently optogenetics has gradually gained recognition as a novel technique to regulate the activity of neurons with light stimulation.
Shanshan Lin   +11 more
doaj   +1 more source

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