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Optogenetics

Current Opinion in Ophthalmology, 2015
In this review, we will discuss the recent developments in optogenetics and their potential applications in ophthalmology to restore vision in retinal degenerative diseases.In recent years, we have seen major advances in the field of optogenetics, providing us with novel opsins for potential applications in the retina.
Duebel, Jens, Marazova, Katia, Sahel, José-Alain   +2 more
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Group-based, autonomous, individualized training and testing of long-tailed macaques (Macaca fascicularis) in their home enclosure to a visuo-acoustic discrimination task

Frontiers in Psychology, 2022
In recent years, the utility and efficiency of automated procedures for cognitive assessment in psychology and neuroscience have been demonstrated in non-human primates (NHP).
Jorge Cabrera-Moreno, Jorge Cabrera-Moreno, Jorge Cabrera-Moreno, Jorge Cabrera-Moreno, Lena Jeanson, Lena Jeanson, Marcus Jeschke, Marcus Jeschke, Marcus Jeschke, Marcus Jeschke, Antonino Calapai, Antonino Calapai, Antonino Calapai, Antonino Calapai   +13 more
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Design of a palette of SNAP-tag mimics of fluorescent proteins and their use as cell reporters

Cell Discovery, 2023
Naturally occurring fluorescent proteins (FPs) are the most widely used tools for tracking cellular proteins and sensing cellular events. Here, we chemically evolved the self-labeling SNAP-tag into a palette of SNAP-tag mimics of fluorescent proteins ...
Dasheng Zhang, Zhengda Chen, Zengmin Du, Bingkun Bao, Ni Su, Xianjun Chen, Yihui Ge, Qiuning Lin, Lipeng Yang, Yujie Hua, Shuo Wang, Xin Hua, Fangting Zuo, Ningfeng Li, Renmei Liu, Li Jiang, Chunyan Bao, Yuzheng Zhao, Joseph Loscalzo, Yi Yang, Linyong Zhu   +20 more
doaj   +1 more source

Flexible auditory training, psychophysics, and enrichment of common marmosets with an automated, touchscreen-based system

Nature Communications, 2022
The authors present a cage-based stand-alone platform for autonomous, standardized, and unsupervised training and testing of visuo-auditory-cued behaviours of common marmosets. The experiments do not require dietary restriction or social separation.
A. Calapai, J. Cabrera-Moreno, T. Moser, M. Jeschke   +3 more
doaj   +1 more source

Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors

Cell Regeneration, 2022
Cell metabolism plays vital roles in organismal development, but it has been much less studied than transcriptional and epigenetic control of developmental programs.
Ting Li, Yejun Zou, Shuning Liu, Yi Yang, Zhuo Zhang, Yuzheng Zhao   +5 more
doaj   +1 more source

A bibliometric profile of optogenetics: quantitative and qualitative analyses

Frontiers in Neuroscience, 2023
IntroductionOptogenetics is a rapidly developing field combining optics and genetics, with promising applications in neuroscience and beyond.
Zhonghan Zhou, Zhonghan Zhou, Zhonghan Zhou, Zhonghan Zhou, Zhonghan Zhou, Xuesheng Wang, Xuesheng Wang, Xuesheng Wang, Xuesheng Wang, Xuesheng Wang, Xunhua Li, Xunhua Li, Xunhua Li, Xunhua Li, Xunhua Li, Limin Liao, Limin Liao, Limin Liao, Limin Liao, Limin Liao, Limin Liao   +20 more
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Optogenetics in plants [PDF]

New Phytologist, 2020
SummaryThe last two decades have witnessed the emergence of optogenetics; a field that has given researchers the ability to use light to control biological processes at high spatiotemporal and quantitative resolutions, in a reversible manner with minimal side‐effects.
Christie, John M., Zurbriggen, Matias D.
openaire   +3 more sources

Optogenetics 3.0 [PDF]

Cell, 2010
Optogenetic methods use light to modulate the activities of target cells in vivo. By improving inter- and intracellular trafficking of light-sensitive switch proteins called opsins, Gradinaru et al. (2010) have developed a new generation of optogenetic tools capable of regulating the activity of targeted neurons with exquisite precision and efficiency.
Liu, Xu, Tonegawa, Susumu
openaire   +3 more sources

A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice

Nature Communications, 2021
Pulsing cellular dynamics in genetic circuits have been shown to provide critical capabilities to cells in stress response, signaling and development.
Ting Li, Xianjun Chen, Yajie Qian, Jiawei Shao, Xie Li, Shuning Liu, Linyong Zhu, Yuzheng Zhao, Haifeng Ye, Yi Yang   +9 more
doaj   +1 more source

Optogenetics: Solving the Enigma of Sleep [PDF]

Sleep Medicine Research, 2018
Sleep is a crucial and evolutionarily conserved phenomenon, but the mechanisms that control sleep-wake behavior and underlie sleep disorders are not yet fully understood.
Victor James Drew, Jae Meen Lee, Tae Kim
doaj   +1 more source