Results 1 to 10 of about 20,998 (119)

X-Optogenetics and U-Optogenetics: Feasibility and Possibilities

Photonics, 2015
Optogenetics is an established technique that uses visible light to modulate membrane voltage in neural cells. Although optogenetics allows researchers to study parts of the brain like never before, it is limited because it is invasive, and visible light
Ge Wang, Lars Gjesteby
exaly   +3 more sources

Design of a palette of SNAP-tag mimics of fluorescent proteins and their use as cell reporters

Cell Discovery, 2023
Naturally occurring fluorescent proteins (FPs) are the most widely used tools for tracking cellular proteins and sensing cellular events. Here, we chemically evolved the self-labeling SNAP-tag into a palette of SNAP-tag mimics of fluorescent proteins ...
Dasheng Zhang, Zhengda Chen, Zengmin Du, Bingkun Bao, Ni Su, Xianjun Chen, Yihui Ge, Qiuning Lin, Lipeng Yang, Yujie Hua, Shuo Wang, Xin Hua, Fangting Zuo, Ningfeng Li, Renmei Liu, Li Jiang, Chunyan Bao, Yuzheng Zhao, Joseph Loscalzo, Yi Yang, Linyong Zhu   +20 more
doaj   +1 more source

Group-based, autonomous, individualized training and testing of long-tailed macaques (Macaca fascicularis) in their home enclosure to a visuo-acoustic discrimination task

Frontiers in Psychology, 2022
In recent years, the utility and efficiency of automated procedures for cognitive assessment in psychology and neuroscience have been demonstrated in non-human primates (NHP).
Jorge Cabrera-Moreno, Jorge Cabrera-Moreno, Jorge Cabrera-Moreno, Jorge Cabrera-Moreno, Lena Jeanson, Lena Jeanson, Marcus Jeschke, Marcus Jeschke, Marcus Jeschke, Marcus Jeschke, Antonino Calapai, Antonino Calapai, Antonino Calapai, Antonino Calapai   +13 more
doaj   +1 more source

Flexible auditory training, psychophysics, and enrichment of common marmosets with an automated, touchscreen-based system

Nature Communications, 2022
The authors present a cage-based stand-alone platform for autonomous, standardized, and unsupervised training and testing of visuo-auditory-cued behaviours of common marmosets. The experiments do not require dietary restriction or social separation.
A. Calapai, J. Cabrera-Moreno, T. Moser, M. Jeschke   +3 more
doaj   +1 more source

Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors

Cell Regeneration, 2022
Cell metabolism plays vital roles in organismal development, but it has been much less studied than transcriptional and epigenetic control of developmental programs.
Ting Li, Yejun Zou, Shuning Liu, Yi Yang, Zhuo Zhang, Yuzheng Zhao   +5 more
doaj   +1 more source

A bibliometric profile of optogenetics: quantitative and qualitative analyses

Frontiers in Neuroscience, 2023
IntroductionOptogenetics is a rapidly developing field combining optics and genetics, with promising applications in neuroscience and beyond.
Zhonghan Zhou, Zhonghan Zhou, Zhonghan Zhou, Zhonghan Zhou, Zhonghan Zhou, Xuesheng Wang, Xuesheng Wang, Xuesheng Wang, Xuesheng Wang, Xuesheng Wang, Xunhua Li, Xunhua Li, Xunhua Li, Xunhua Li, Xunhua Li, Limin Liao, Limin Liao, Limin Liao, Limin Liao, Limin Liao, Limin Liao   +20 more
doaj   +1 more source

Optogenetics: Solving the Enigma of Sleep [PDF]

Sleep Medicine Research, 2018
Sleep is a crucial and evolutionarily conserved phenomenon, but the mechanisms that control sleep-wake behavior and underlie sleep disorders are not yet fully understood.
Victor James Drew, Jae Meen Lee, Tae Kim
doaj   +1 more source

Emerging optogenetics technologies in biomedical applications

Smart Medicine, 2023
Optogenetics is a cutting‐edge technology that merges light control and genetics to achieve targeted control of tissue cells. Compared to traditional methods, optogenetics offers several advantages in terms of time and space precision, accuracy, and ...
Haozhen Ren, Yi Cheng, Gaolin Wen, Jinglin Wang, Min Zhou   +4 more
doaj   +1 more source

A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice

Nature Communications, 2021
Pulsing cellular dynamics in genetic circuits have been shown to provide critical capabilities to cells in stress response, signaling and development.
Ting Li, Xianjun Chen, Yajie Qian, Jiawei Shao, Xie Li, Shuning Liu, Linyong Zhu, Yuzheng Zhao, Haifeng Ye, Yi Yang   +9 more
doaj   +1 more source

Advances in optogenetic studies of depressive-like behaviors and underlying neural circuit mechanisms

Frontiers in Psychiatry, 2022
BackgroundsThe neural circuit mechanisms underlying depression remain unclear. Recently optogenetics has gradually gained recognition as a novel technique to regulate the activity of neurons with light stimulation.
Shanshan Lin, Shanshan Lin, Yiwei Du, Yiwei Du, Yujie Xia, Yujie Xia, Yumeng Xie, Yumeng Xie, Ling Xiao, Ling Xiao, Gaohua Wang, Gaohua Wang   +11 more
doaj   +1 more source