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The Roles of Optogenetics and Technology in Neurobiology: A Review
Frontiers in Aging Neuroscience, 2022 Optogenetic is a technique that combines optics and genetics to control specific neurons. This technique usually uses adenoviruses that encode photosensitive protein. The adenovirus may concentrate in a specific neural region.
Wenqing Chen +13 more
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Photonics, 2019 Dissecting the functional roles of neuronal circuits and their interaction is a crucial step in basic neuroscience and in all the biomedical field. Optogenetics is well-suited to this purpose since it allows us to study the functionality of neuronal ...
Elena Montagni +3 more
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Optogenetics and Chemogenetics [PDF]
, 2018 Optogenetics and chemogenetics provide the ability to modulate neurons in a type- and region-specific manner. These powerful techniques are useful to test hypotheses regarding the neural circuit mechanisms of general anesthetic end points such as hypnosis and analgesia.
Ksenia, Vlasov +2 more
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Prospects for optogenetic augmentation of brain function
Frontiers in Systems Neuroscience, 2015 The ability to optically control neural activity opens up possibilities for the restoration of normal function following neurological disorders. The temporal precision, spatial resolution and neuronal specificity that optogenetics offers is unequalled by
Sarah eJarvis +3 more
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NHP Optogenetics Open Database
, 2021 The NHP Optogenetics Open Database provides a portal for NHP researchers around the world to view and share their results using optogenetics in NHP. It contains a detailed list of viral injection attempts and their outcome, whether positive or negative.
Sebastien Tremblay
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Rods progressively escape saturation to drive visual responses in daylight conditions
Nature Communications, 2017 Rod photoreceptors are thought to be saturated under bright light. Here, the authors describe the physiological parameters that mediate response saturation of rod photoreceptors in mouse retina, and show that rods can drive visual responses in photopic ...
Alexandra Tikidji-Hamburyan +14 more
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AAV1 is the optimal viral vector for optogenetic experiments in pigeons (Columba livia)
Communications Biology, 2021 Rook et al. establish a viral gene transfer system to perform optogenetics in pigeons. They deliver ChR2 via AAV1 into the visual entopallium and show its behavioral relevance for contrast perception, verifying the applicability of optogenetics in an ...
Noemi Rook +6 more
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Bioluminescence-Driven Optogenetics
Life, 2020 Bioluminescence-based technologies are among the most commonly used methods to quantify and visualise physiology at the cellular and organismal levels.
Macià Sureda-Vives, Karen S. Sarkisyan
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Applications and challenges of rhodopsin-based optogenetics in biomedicine
Frontiers in Neuroscience, 2022 Optogenetics is an emerging bioengineering technology that has been rapidly developed in recent years by cross-integrating optics, genetic engineering, electrophysiology, software control, and other disciplines.
Hanci Zhang +9 more
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Optogenetics in epilepsy [PDF]
Neurosurgical Focus, 2013 Optogenetics, the use of light to stimulate or inhibit neural circuits via viral transduction of protein channels, has emerged as a possible method of treating epilepsy. By introducing viral vectors carrying algal-derived cation or anion channels, known as opsins, neurons that initiate or propagate seizures may be silenced.
J Nicole, Bentley +3 more
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