Results 51 to 60 of about 28,756 (283)

Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics [PDF]

, 2013
Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Here we describe red, single-wavelength GECIs, RCaMPs, engineered from circular permutation of the thermostable red fluorescent protein mRuby.
Looger, Loren L, Tolö, Johan, Michael B Orger, Leon eLagnado, Tian, Lin, Pulver, Stefan R., Marvin, Jonathan S, Gottschalk, Alexander, Lin eTian, Leon Lagnado, Carreras Calderón, Nicole, Jasper eAkerboom, Kristen E Severi, Eric R Schreiter, Kristen E. Severi, Ronak ePatel, Alexander Gottschalk, Matthias ePrigge, Nicole Carreras Calderón, Kim, Douglas S, Lin Tian, Cornelia I Bargmann, Calderon, Nicole Carreras, Marvin, Jonathan S., Sebastian eKügler, Jasper Akerboom, Douglas S Kim, Douglas S. Kim, Orger, Michael B, Tsai-Wen eChen, Macklin, John J., Sebastian Wabnig, Tsai-Wen Chen, Elisabeth Fischer, Alexander eGottschalk, Elisabeth eFischer, Sarkisyan, Karen S, Marvin, Jonathan, Schreiter, Eric, Matthias Prigge, Wardill, Trevor J, Andrew eGordus, John J Macklin, Schüler, Christina, Trevor J. Wardill, Ronak Patel, Sebastian eWabnig, Severi, Kristen E., Nicole eCarreras Calderón, Severi, Kristen E, Loren L. Looger, Trevor J Wardill, Karen S. Sarkisyan, Christina Schüler, Fischer, Elisabeth, Patel, Ronak, Hegemann, Peter, Stefan R Pulver, Pulver, Stefan R, Kügler, Sebastian, Wardill, Trevor, Eric R. Schreiter, Loren L Looger, Wabnig, Sebastian, Jonathan S. Marvin, Johan Tolö, Sebastian Kügler, Schreiter, Eric R., Patel, Ronak Bhailal, Cornelia I. Bargmann, Sarkisyan, Karen S., Schueler, Christina, John J. Macklin, Andrew Gordus, Karen S Sarkisyan, Chen, Tsai-Wen, Bargmann, Cornelia I., Jonathan S Marvin, Looger, Loren L., Kim, Douglas S., Orger, Michael B., Schreiter, Eric R, Lagnado, Leon, Johan eTolö, Peter Hegemann, Orger, Michael, Prigge, Matthias, Bargmann, Cornelia I, Gordus, Andrew, Christina eSchüler, Stefan R. Pulver, Michael B. Orger, Wardill, Trevor J., Severi, Kristen, Bargmann, Cornelia, Peter eHegemann, Akerboom, Jasper, Macklin, John J, Pulver, Stefan R; id_orcid   +98 more
core   +1 more source

Optogenetics — The Might of Light

New England Journal of Medicine, 2021
Optogenetics Recognized through the Lasker Award This year’s Lasker Basic Medical Research Award goes to Drs.
openaire   +3 more sources

Emerging Post‐CMOS Hardware Neurons for Brain‐Inspired Computing: Devices, Circuits, and System Integration

Advanced Functional Materials, EarlyView.
The physical realization of artificial neurons is a critical challenge for energy‐efficient neuromorphic computing. This review presents a comprehensive analysis of the evolution of artificial neuron implementations from conventional CMOS to emerging post‐CMOS technologies.
Kannan Udaya Mohanan, Hocheon Yoo, Benoît H. Lessard, Ioannis Kymissis, Chang‐Hyun Kim   +4 more
wiley   +1 more source

2D Skeletal Muscle Thin Film Actuators Enhance Efficiency of Biohybrid Robots

Advanced Functional Materials, EarlyView.
2D skeletal muscle thin film actuators generate millinewton‐scale forces and millimeter‐scale strokes while remaining functional for over 30 days. Their force density is 20‐fold higher than 3D skeletal muscle actuators, enabling multi‐fin robots with tunable speed and multidirectional steering.
Maheera Bawa, Arielle Berman, Laura Schwendeman, Ferdows Afghah, Seanbiron Johnson, Ritu Raman   +5 more
wiley   +1 more source

Nonhuman primate optogenetics: Recent advances and future directions

, 2017
\ua9 2017 the authors. Optogenetics is the use of genetically coded, light-gated ion channels or pumps (opsins) for millisecond resolution control of neural activity.
El-Shamayleh Y, Schmid MC, Galvan A, Acker L, Stauffer WR, Ohayon S, Inoue K-I   +6 more
core   +3 more sources

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of Ca²⁺ Signaling Mechanisms Using Optogenetic Tools

Cells, 2021
Calcium ion channels are involved in numerous biological functions such as lymphocyte activation, muscle contraction, neurotransmission, excitation, hormone secretion, gene expression, cell migration, memory, and aging.
Lena Maltan, Hadil Najjar, Adéla Tiffner, Isabella Derler   +3 more
doaj   +1 more source

Optogenetics in preclinical neuroscience and psychiatry research: recent insights and potential applications [PDF]

, 2014
Ross A McDevitt,1 Sean J Reed,2 Jonathan P Britt2,3 1Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA; 2Integrated Program in Neuroscience, Montreal Neurological Institute, 3Department of ...
Reed SJ, Britt JP, McDevitt RA
core  

Cardiac optogenetics

American Journal of Physiology-Heart and Circulatory Physiology, 2013
Optogenetics is an emerging technology for optical interrogation and control of biological function with high specificity and high spatiotemporal resolution. Mammalian cells and tissues can be sensitized to respond to light by a relatively simple and well-tolerated genetic modification using microbial opsins (light-gated ion channels and pumps).
openaire   +3 more sources

Additively Manufactured Geometry‐Reconfigurable Soft Neural Probes With Monolithic Multifunctionality

Advanced Functional Materials, EarlyView.
A geometry‐reconfigured additive manufacturing strategy converts planar printed soft materials into soft compact neural probes with integrated hydrogel electrodes and microfluidic channels. The resulting NeuroMAP platform enables scalable multichannel recording, localized chemical delivery, stable in vivo electrophysiological recording, and reduced ...
Hyunjin Lee, Xinyi Wang, Sirui Li, Jihyang Park, Hyunseok Lee, Jianting Yao, Kedar Narayan, Yuqi Wang, Jiashu Ren, Yueqi Deng, Salahuddin Ahmed, Denver I. Greenawalt, Archana Pandiyan, Loganathan Veeramuthu, Chi‐Ching Kuo, Tao Zhou   +15 more
wiley   +1 more source