A Light Wand to Untangle the Myocardial Cell Network
Methods and Protocols, 2019 The discovery of optogenetics has revolutionized research in neuroscience by providing the tools for noninvasive, cell-type selective modulation of membrane potential and cellular function in vitro and in vivo. Rhodopsin-based optogenetics has later been
Tania Zaglia +2 more
doaj +1 more source
Analyzing efficacy, stability, and safety of AAV-mediated optogenetic hearing restoration in mice
Life Science Alliance, 2022 This longitudinal study revealed stable expression of the fast-gating channelrhodopsin f-Chrimson in cochlear neurons of mice over at least 2 yr upon a single postnatal AAV dosing of the cochlea.
Burak Bali +4 more
doaj +1 more source
Non-viral delivery and optimized optogenetic stimulation of retinal ganglion cells led to behavioral restoration of vision [PDF]
, 2012 Stimulation of retinal neurons using optogenetics via use of chanelrhodopsin-2 (ChR2) has opened up a new direction for restoration of vision for treatment of retinitis pigmentosa (RP).
Edward Wong +5 more
core +2 more sources
Optogenetics: Emerging strategies for neuropathic pain treatment
Frontiers in Neurology, 2022 Neuropathic pain (NP) is a chronic health condition that presents a significant burden on patients, society, and even healthcare systems. However, in recent years, an emerging field in the treatment of neuropathic pain – optogenetic technology has dawned,
Siyu Li +3 more
doaj +1 more source
Optogenetics: Background, Methodological Advances and Potential Applications for Cardiovascular Research and Medicine [PDF]
, 2020 Optogenetics is an elegant approach of precisely controlling and monitoring the biological functions of a cell, group of cells, tissues, or organs with high temporal and spatial resolution by using optical system and genetic engineering technologies. The
Joshi, Jyotsna +2 more
core +1 more source
Exploring adult hippocampal neurogenesis using optogenetics [PDF]
, 2018 In the 1980s, it was widely accepted that new neurons are continuously generated in the dentate gyrus of the mammalian hippocampus. Since its acceptance, researchers have employed various techniques and behavioral paradigms to study the proliferation ...
Pinardo, Heinrich
core
Curvy surface conformal ultra-thin transfer printed Si optoelectronic penetrating microprobe arrays [PDF]
, 2018 Penetrating neural probe arrays are powerful bio-integrated devices for studying basic neuroscience and applied neurophysiology, underlying neurological disorders, and understanding and regulating animal and human behavior.
Li, Yanbin +4 more
core +2 more sources
An Engineered Living Material With Pro‐Angiogenic Activity Inducible by Near‐Infrared Light
Advanced Functional Materials, EarlyView.NIR‐responsive engineered living materials (ELMs) for controlled angiogenesis: Near‐infrared (800 nm) light activates engineered probiotic bacteria within alginate‐based living materials to secrete a blood vessel‐regenerating protein. The released protein promotes pro‐angiogenic effects in endothelial networks and chick chorioallantoic membranes.
Anwesha Chatterjee +4 more
wiley +1 more source
Optogenetics Therapy of Human Cancers
Zhongliu Fangzhi Yanjiu, 2018 The optogenetics approach uses a combination of genetic and optical methods to control the functions in specific cells of biological tissues. Since the control of neuronal activity by irradiating channelrhodopsin-2 with blue light was reported in 2005 ...
ZHANG Baihong, YUE Hongyun
doaj +1 more source
Optogenetics in primates: monkey see monkey look [PDF]
, 2011 Optogenetics has emerged as a powerful tool for studying the neural basis of simple behaviors in rodents and small animals. In the primate model, however, optogenetics has had limited utility because optical methods have not been able to drive behavior ...
Gregory Horwitz +2 more
core +1 more source