Results 21 to 30 of about 25,913 (283)
Optogenetics in epilepsy [PDF]
Neurosurgical Focus, 2013 Optogenetics, the use of light to stimulate or inhibit neural circuits via viral transduction of protein channels, has emerged as a possible method of treating epilepsy. By introducing viral vectors carrying algal-derived cation or anion channels, known as opsins, neurons that initiate or propagate seizures may be silenced.
J Nicole, Bentley +3 more
openaire +2 more sources
Optogenetics-Inspired Fluorescent Synaptic Devices with Nonvolatility
, 2023 Given the synergy of optogenetics and bioimaging in neuroscience, it is possible for light to simultaneously modulate and visualize synaptic events of optoelectronic synaptic devices, which are building blocks of a neuromorphic computing system with ...
Wandong Gao (14572256) +10 more
core +1 more source
Nature Communications, 2021 Pulsing cellular dynamics in genetic circuits have been shown to provide critical capabilities to cells in stress response, signaling and development.
Ting Li +9 more
doaj +1 more source
Micro mirror arrays as high-resolution spatial light modulators for photoactivation and optogenetics
, 2022 Paper 8586UThe ability to control the illumination and imaging paths of optical microscopes is an essential part of advanced fluorescence microscopy, and a powerful tool for optogenetics.
Heintzmann, R. +5 more
core +1 more source
Frontiers in Psychiatry, 2022 BackgroundsThe neural circuit mechanisms underlying depression remain unclear. Recently optogenetics has gradually gained recognition as a novel technique to regulate the activity of neurons with light stimulation.
Shanshan Lin +11 more
doaj +1 more source
Optogenetics in stem cell research: Focus on the central nervous system
, 2022 S.75-87Stem cell-based therapies of CNS disorders represent a promising approach in translational and regenerative medicine. Stem cell-based tissue replacement and regeneration would, for the first time, offer a causal treatment strategy which is most ...
Boltze, J., Stroh, A.
core +1 more source
Nature Communications, 2023 Optogenetics tools for precise temporal and spatial control of protein abundance are valuable in studying diverse complex biological processes. In the present study, we engineer a monomeric tag of stabilization upon light induction (SULI) for yeast and ...
Miaowei Mao +6 more
doaj +1 more source
Cell, 2010 Optogenetic methods use light to modulate the activities of target cells in vivo. By improving inter- and intracellular trafficking of light-sensitive switch proteins called opsins, Gradinaru et al. (2010) have developed a new generation of optogenetic tools capable of regulating the activity of targeted neurons with exquisite precision and efficiency.
Liu, Xu, Tonegawa, Susumu
openaire +3 more sources
Step Sequence is a Critical Gait Parameter of Unilateral 6-OHDA Parkinson's Rat Models
Cell Transplantation, 2017 Parkinson's disease is a progressive neurological disorder, marked by the loss of dopaminergic neurons in the nigrostriatal pathway that leads to abnormal gait, rigidity, slowness of movement, and tremor.
Heather A. Baldwin +4 more
doaj +1 more source
Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics [PDF]
, 2013 Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Here we describe red, single-wavelength GECIs, RCaMPs, engineered from circular permutation of the thermostable red fluorescent protein mRuby.
Looger, Loren L +97 more
core +1 more source