Modeling Interference-Free Neuron Spikes with Optogenetic Stimulation [PDF]
, 2019 This paper predicts the ability to externally control the firing times of a cortical neuron whose behavior follows the Izhikevich neuron model. The Izhikevich neuron model provides an efficient and biologically plausible method to track a cortical neuron'
Eckford, Andrew W. +3 more
core +2 more sources
Step Sequence is a Critical Gait Parameter of Unilateral 6-OHDA Parkinson's Rat Models
Cell Transplantation, 2017 Parkinson's disease is a progressive neurological disorder, marked by the loss of dopaminergic neurons in the nigrostriatal pathway that leads to abnormal gait, rigidity, slowness of movement, and tremor.
Heather A. Baldwin +4 more
doaj +1 more source
Three-dimensional scanless holographic optogenetics with temporal focusing (3D-SHOT). [PDF]
, 2017 Optical methods capable of manipulating neural activity with cellular resolution and millisecond precision in three dimensions will accelerate the pace of neuroscience research. Existing approaches for targeting individual neurons, however, fall short of
Adesnik, Hillel +5 more
core +2 more sources
The Roles of Optogenetics and Technology in Neurobiology: A Review
Frontiers in Aging Neuroscience, 2022 Optogenetic is a technique that combines optics and genetics to control specific neurons. This technique usually uses adenoviruses that encode photosensitive protein. The adenovirus may concentrate in a specific neural region.
Wenqing Chen +13 more
doaj +1 more source
Real-time optical manipulation of cardiac conduction in intact hearts [PDF]
, 2018 Optogenetics has provided new insights in cardiovascular research, leading to new methods for cardiac pacing, resynchronization therapy and cardioversion.
Bocchi, L. +16 more
core +2 more sources
Rods progressively escape saturation to drive visual responses in daylight conditions
Nature Communications, 2017 Rod photoreceptors are thought to be saturated under bright light. Here, the authors describe the physiological parameters that mediate response saturation of rod photoreceptors in mouse retina, and show that rods can drive visual responses in photopic ...
Alexandra Tikidji-Hamburyan +14 more
doaj +1 more source
Separate roles of PKA and EPAC in renal function unraveled by the optogenetic control of cAMP levels in vivo [PDF]
, 2013 Cyclic AMP (cAMP) is a ubiquitous second messenger that regulates a variety of essential processes in diverse cell types, functioning via cAMP-dependent effectors such as protein kinase A (PKA) and/or exchange proteins directly activated by cAMP (EPAC ...
Akbari +60 more
core +1 more source
Prospects for optogenetic augmentation of brain function
Frontiers in Systems Neuroscience, 2015 The ability to optically control neural activity opens up possibilities for the restoration of normal function following neurological disorders. The temporal precision, spatial resolution and neuronal specificity that optogenetics offers is unequalled by
Sarah eJarvis +3 more
doaj +1 more source
AAV1 is the optimal viral vector for optogenetic experiments in pigeons (Columba livia)
Communications Biology, 2021 Rook et al. establish a viral gene transfer system to perform optogenetics in pigeons. They deliver ChR2 via AAV1 into the visual entopallium and show its behavioral relevance for contrast perception, verifying the applicability of optogenetics in an ...
Noemi Rook +6 more
doaj +1 more source
Timing Control of Single Neuron Spikes with Optogenetic Stimulation [PDF]
, 2018 This paper predicts the ability to externally control the firing times of a cortical neuron whose behavior follows the Izhikevich neuron model. The Izhikevich neuron model provides an efficient and biologically plausible method to track a cortical neuron'
Eckford, Andrew W. +3 more
core +2 more sources