Results 71 to 80 of about 44,262 (332)
Optogenetic Microwell Array Screening System: A High-Throughput Engineering Platform for Genetically Encoded Fluorescent Indicators [PDF]
, 2023 Michael Rappleye +9 more
openalex +1 more source
Advanced Science, EarlyView.Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat +6 more
wiley +1 more source
Photonic Nanojet‐Mediated Optogenetics
Advanced Science, 2022 Optogenetics has become a widely used technique in neuroscience research, capable of controlling neuronal activity with high spatiotemporal precision and cell‐type specificity.
Jinghui Guo +22 more
doaj +1 more source
The Journal of the Institute of Image Information and Television Engineers, 2012 This chapter defines optogenetics as an experiment that uses a combination of genetic manipulation and optics. Optogenetics can be used for studies of the autonomic areas of the brain and provides tools for specific control of phenotypically identified groups of neurons and more recently, astrocytes.
Takashi Tokuda, Jun Ohta
openaire +4 more sources
Hierarchical Summary Statistics Encoding Across Primary Visual and Posterior Parietal Cortices
Advanced Science, EarlyView.This study shows that mouse V1 simultaneously encodes the ensemble mean and variance of motion, providing a robust summary‐statistic representation that persists despite single‐neuron variability. These signals propagate to PPC, where they are transformed into abstract category representations during decision making.
Young‐Beom Lee +4 more
wiley +1 more source
Neuronal optogenetics as a new topic of technology assessment?
TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und PraxisThis article is intended as a sketchy reflection on the question of the extent to which neuronal optogenetics could become a future topic of technology assessment (TA).
Hans Zillmann
doaj +1 more source
Towards circuit optogenetics [PDF]
Current Opinion in Neurobiology, 2018 Optogenetics neuronal targeting combined with single-photon wide-field illumination has already proved its enormous potential in neuroscience, enabling the optical control of entire neuronal networks and disentangling their role in the control of specific behaviors. However, establishing how a single or a sub-set of neurons controls a specific behavior,
Chen, I-Wen +2 more
openaire +3 more sources
Keeping track of worm trackers [PDF]
, 2012 C. elegans is used extensively as a model system in the neurosciences due to its well defined nervous system. However, the seeming simplicity of this nervous system in anatomical structure and neuronal connectivity, at least compared to higher animals ...
Gottschalk, Alexander +3 more
core +1 more source
A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain
Advanced Science, EarlyView.Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang +15 more
wiley +1 more source
Advanced Science, EarlyView.This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber +12 more
wiley +1 more source