Results 91 to 100 of about 44,262 (332)
Advanced Science, EarlyView.Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei +15 more
wiley +1 more source
Optogenetics: Novel Tools for Controlling Mammalian Cell Functions with Light
International Journal of Photoenergy, 2014 In optogenetics, targeted illumination is used to control the functions of cells expressing exogenous light-activated proteins. Adoption of the optogenetic methods has expanded rapidly in recent years.
Toshihiro Kushibiki +3 more
doaj +1 more source
Root Mean Square Error of Neural Spike Train Sequence Matching with Optogenetics
, 2017 Optogenetics is an emerging field of neuroscience where neurons are genetically modified to express light-sensitive receptors that enable external control over when the neurons fire.
Eckford, Andrew W. +2 more
core +1 more source
Advanced Science, EarlyView.Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji +13 more
wiley +1 more source
Frontiers in Neural CircuitsOptogenetics and chemogenetics are emerging neuromodulation techniques that have attracted significant attention in recent years. These techniques enable the precise control of specific neuronal types and neural circuits, allowing researchers to ...
Shaowei Li +5 more
doaj +1 more source
Decoding Naturalistic Episodic Memory with Artificial Intelligence and Brain‐Machine Interface
Advanced Science, EarlyView.Episodic memory weaves together what, where, and when of experience into a personal narrative. Cutting‐edge AI models may decode this intricate process in real‐life settings, revealing how neural activity encodes naturalistic memories. By merging AI with brain–machine interfaces, researchers are edging closer to mapping and even engineering memory ...
Dong Song
wiley +1 more source
Advanced Science, EarlyView.Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian +13 more
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Neurobiology of Disease, 2014 The misfolding and aggregation of α-synuclein (aSyn) eventually lead to an accumulation of toxic forms that disturb normal neuronal function and result in cell death.
Mari H. Savolainen +5 more
doaj +1 more source