Results 91 to 100 of about 28,756 (283)

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Optogenetics in primates: monkey see monkey look [PDF]

, 2011
Optogenetics has emerged as a powerful tool for studying the neural basis of simple behaviors in rodents and small animals. In the primate model, however, optogenetics has had limited utility because optical methods have not been able to drive behavior ...
Gregory Horwitz, Mehrdad Jazayeri, Zachary Lindbloom-Brown   +2 more
core  

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source

Target-dependent routing of sensory information in the olfactory system

Communications Biology
Parallel processing, the ability to split the information content of sensory stimuli and handle them simultaneously, is essential for sensory perception in many systems.
Kim Le-Jahns, Siran Sireci, Jan Mayland, Franziska Richter, Pablo Chamero, Martin K. Schwarz, Daniela Brunert, Markus Rothermel   +7 more
doaj   +1 more source

The past, present and future of light-gated ion channels and optogenetics

eLife, 2018
The discovery of the mechanisms underlying light-gated ion channels called channelrhodospins and the subsequent development of optogenetics illustrates how breakthroughs in science and technology can span multiple levels of scientific inquiry.
Sheena A Josselyn
doaj   +1 more source

Origin of Enhanced Efficiency and Reduced Roll‐Off in Organic Light‐Emitting Diodes Based on Pt(II) Complexes

Advanced Science, EarlyView.
Controlled Pt–Pt fine structure in square‐planar Pt(II) complexes governs metal–metal‐to‐ligand charge‐transfer (MMLCT) state formation, exciton dynamics, and organic light‐emitting diode performance. Short Pt–Pt contacts in Pt(fppz)2 enable coherent metal–metal coupling, sub‐microsecond emission and an external quantum efficiency of 29%, whereas ...
Atul Shukla, Sarah K. M. McGregor, Julian A. Steele, Innes K. Gale, Kiyoshi Miyata, Monirul Hassan, Christian McDonald, Romain J. Lepage, Eduardo Solano, Pilankatta K. Ramya, Cherumuttathu H. Suresh, Takumi Ehara, Chihaya Adachi, Ken Onda, Shih‐Chun Lo, Ebinazar B. Namdas   +15 more
wiley   +1 more source

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source

An Open Resource for Non-human Primate Optogenetics

, 2020
Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on animal models more closely related to humans, such as non-human primates (NHPs), has been mixed.
Caiola, M., Gulli, R., Albaugh , D., Spudich , J., Galvan, A., Tang, S., Schultz, W., Mendoza-Halliday , D., Desimone, R., Aschner, A., Kar, K., Amita, H., Sommer, M., Senova, Y., Thiele, A., El-Nahal, H., Ju, N., Martinez-Trujillo , J., Bohlen, M., Andrei, A., Petkov, C., Hosseini , E., Komatsu , M., Shadlen, M., Inoue , K., Klein, C., Xu, H., Treue, S., Egger, S., Takada , M., Calcedo, R., Maunsell, J., Muers, R., Dragoi , V., Saunders, R., Kohn, A., Scherberger, H., Shenoy, K., Eldridge, M., Gail, A., Platt, M., Nurminen, L., Fetsch, C., DiCarlo , J., Dai, J., Monosov , I., Ramakrishnan, C., Basso, M., Hu, X., Clark, A., Debes, S., Whitmire , M., Tremblay, S., Chen, Y., Janz, R., Pojoga , S., Benvenuti , G., Siu, C., Wichmann, T., Yazdan-Shahmorad , A., Fortuna, M., Fujii, N., O'Shea , D., Vogels, R., Afraz, A., Matsumoto, M., Vanduffel , W., Remington, E., Ghosh, S., Hikosaka , O., Deisseroth, K., Acker, L., Schmid, M., Solomon, S., Hüer, J., Federer, F., Sabes , P., Fabbrini , F., Jazayeri, M., Angelucci, A., Seidemann , E., Ortiz-Rios , M., Roe, A., Friedman , R., Maeda, K., Balan, P., Cavanaugh , J., Palfi, S., Wurtz , R., Stauffer, W., Smith, Y., Sheinberg, D., Rajalingham , R., Chernov, M., Gieselmann, M., Jiang, R., Revsine , D.   +96 more
core   +2 more sources

Epidural optogenetics for controlled analgesia

Molecular Pain, 2016
Background Optogenetic tools enable cell selective and temporally precise control of neuronal activity; yet, difficulties in delivering sufficient light to the spinal cord of freely behaving animals have hampered the use of spinal optogenetic approaches ...
Robert P Bonin PhD, Feng Wang PhD, Mireille Desrochers-Couture, Alicja Ga¸secka PhD, Marie-Eve Boulanger, Daniel C Côté PhD, Yves De Koninck PhD   +6 more
doaj   +1 more source