Results 111 to 120 of about 18,335 (296)
Small, EarlyView.NIR‐mediated photo‐switching drug delivery system for the remote‐control differentiation of NSCs. Left: NIR‐mediated curcumin release is induced by NIR‐to‐UV photon upconversion in a photo‐controllable manner. Curcumin is bound in the minor groove of the synthesized DNA construct containing AAP photo‐switchers. Right: The rational design of several AAP
Thanapat Pongkulapa +8 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2014 The GABAergic system is the main source of inhibition in the mammalian brain. Consequently, much effort is still made to develop new modulators of GABAergic synaptic transmission.
Julien eDine +3 more
doaj +1 more source
Longitudinal Optogenetic Motor Mapping Revealed Structural and Functional Impairments and Enhanced Corticorubral Projection after Contusive Spinal Cord Injury in Mice [PDF]
, 2019 Current evaluation of impairment and repair after spinal cord injury (SCI) is largely dependent on behavioral assessment and histological analysis of injured tissue and pathways. Here, we evaluated whether transcranial optogenetic mapping of motor cortex
Chai, Zhi +5 more
core +1 more source
Yellow Optogenetics with Volvox Channelrhodopsin Variants [PDF]
Biophysical Journal, 2012 Channelrhodopsins (ChR) are light-gated ion channels and rhodopsins with internal ion conducting pores. In 2001 ChR1 and ChR2 cDNAs were identified in Chlamydomonas reinhardtii data bases. The isomerization of the all-trans-retinal chromophore induces conformational changes of the protein that result in the opening of the channel pore to allow ion flow
Matthias Prigge +5 more
openaire +2 more sources
British Journal of Pharmacology, EarlyView.Graph‐based algorithms that enable efficient computations of all H‐bonds present in structures in entire datasets allow us to dissect H‐bond fingerprints that characterize distinct GPCRs and the structures sampled along their activation. Abstract Changes in structure and dynamics elicited by agonist ligand binding at the extracellular side of G protein
Éva Bertalan +3 more
wiley +1 more source
Optogenetic Pacing: Current Insights and Future Potential
Research Reports in Clinical Cardiology, 2020 Airong Li, Rudolph E Tanzi Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USACorrespondence: Airong Li; Rudolph E TanziGenetics and Aging Research Unit, Department of
Li A, Tanzi RE
doaj
Principles of Optogenetic Methods and Their Application to Cardiac Experimental Systems
Frontiers in Physiology, 2019 Optogenetic techniques permit studies of excitable tissue through genetically expressed light-gated microbial channels or pumps permitting transmembrane ion movement.
Emily A. Ferenczi +3 more
doaj +1 more source
Machine learning-guided directed evolution for protein engineering [PDF]
, 2019 Machine learning (ML)-guided directed evolution is a new paradigm for biological design that enables optimization of complex functions. ML methods use data to predict how sequence maps to function without requiring a detailed model of the underlying ...
Arnold, Frances H. +2 more
core +1 more source
CAV-2 Vector Development and Gene Transfer in the Central and Peripheral Nervous Systems [PDF]
, 2019 The options available for genetic modification of cells of the central nervous system (CNS) have greatly increased in the last decade. The current panoply of viral and nonviral vectors provides multifunctional platforms to deliver expression cassettes to
Amani Wehbi +7 more
core +2 more sources
Epilepsia, EarlyView.Abstract Objective Degeneration of hilar mossy cells in the dentate gyrus is an important hallmark of hippocampal sclerosis and is often observed in patients with temporal lobe epilepsy. To understand the pathogenesis of hippocampal sclerosis and develop novel neuroprotective treatments, it is critical to determine the mechanistic processes of mossy ...
Carolin Christina Koretz +5 more
wiley +1 more source