Results 111 to 120 of about 17,118 (247)

Temporal evolution of helix hydration in a light-gated ion channel correlates with ion conductance [PDF]

, 2015
The discovery of channelrhodopsins introduced a new class of light-gated ion channels, which when genetically encoded in host cells resulted in the development of optogenetics. Channelrhodopsin-2 from Chlamydomonas reinhardtii, CrChR2, is the most widely
Bamann, Christian, Bamberg, Ernst, Heberle, Joachim, Resler, Tom, Schlesinger, Ramona, Víctor A. Lórenz-Fonfría   +5 more
core   +1 more source

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

Journal of Internal Medicine, Volume 299, Issue 3, Page 302-327, March 2026.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source

Kalium channelrhodopsins effectively inhibit neurons

Nature Communications
AbstractThe analysis of neural circuits has been revolutionized by optogenetic methods. Light-gated chloride-conducting anion channelrhodopsins (ACRs)—recently emerged as powerful neuron inhibitors. For cells or sub-neuronal compartments with high intracellular chloride concentrations, however, a chloride conductance can have instead an activating ...
Stanislav Ott, Sangyu Xu, Nicole Lee, Ivan Hong, Jonathan Anns, Danesha Devini Suresh, Zhiyi Zhang, Xianyuan Zhang, Raihanah Harion, Weiying Ye, Vaishnavi Chandramouli, Suresh Jesuthasan, Yasunori Saheki, Adam Claridge-Chang   +13 more
openaire   +4 more sources

Channelrhodopsin Photochromic Reactions Provide Multicolor Optogenetic Control [PDF]

Biophysical Journal, 2014
In this issue of the Biophysical Journal, Venkatachalam and Cohen (1) present an innovative combination of opsin-based optogenetic voltage control with simultaneous imaging of green fluorescent protein (GFP)-based sensors. The challenge is that the overlapping absorption spectra of GFP derivatives and the commonly used blue-light activated ChR2-based ...
openaire   +2 more sources

Design and Implementation of a Simulation Framework for a Bio–Neural Dust System

Modelling
This paper presents the development of a computer simulation framework, designed as a cost–effective and technically efficient alternative to experimental studies.
Oussama Abderrahmane Dambri, Arash Azarnoush, Dimitrios Makrakis, Gabriel Levesque, Maja Witter, Abdelhakim Senhaji Hafid   +5 more
doaj   +1 more source

Organization of Valence-Encoding and Projection-Defined Neurons in the Basolateral Amygdala

Cell Reports, 2018
The basolateral amygdala (BLA) mediates associative learning for both fear and reward. Accumulating evidence supports the notion that different BLA projections distinctly alter motivated behavior, including projections to the nucleus accumbens (NAc ...
Anna Beyeler, Chia-Jung Chang, Margaux Silvestre, Clémentine Lévêque, Praneeth Namburi, Craig P. Wildes, Kay M. Tye   +6 more
doaj   +1 more source

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain. [PDF]

, 2015
© 2015 The Authors.Objective: Although Glucagon-like peptide 1 is a key regulator of energy metabolism and food intake, the precise location of GLP-1 receptors and the physiological relevance of certain populations is debatable.
Cork, SC, Gribble, FM, Holt, MK, Reimann, F, Richards, JE, Trapp, S   +5 more
core   +2 more sources

The power of ionic movements in plants

New Phytologist, Volume 249, Issue 5, Page 2232-2240, March 2026.
Summary The movement of ion‐driven electrogenic events known as plant action potentials in the Venus flytrap Dionaea muscipula has first been recognized in Darwin's time. Besides electrophysiological techniques making use of current‐ and voltage‐recording electrodes, today an ever‐growing spectrum of tools has become available, that report online ...
Rainer Hedrich, Ines Kreuzer
wiley   +1 more source

Optogenetic Pacing: Current Insights and Future Potential

Research Reports in Clinical Cardiology, 2020
Airong Li, Rudolph E Tanzi Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USACorrespondence: Airong Li; Rudolph E TanziGenetics and Aging Research Unit, Department of
Li A, Tanzi RE
doaj  

Ion Channel Properties of a Cation Channelrhodopsin, Gt_CCR4

Applied Sciences, 2019
We previously reported a cation channelrhodopsin, Gt_CCR4, which is one of the 44 types of microbial rhodopsins from a cryptophyte flagellate, Guillardia theta.
Shunta Shigemura, Shoko Hososhima, Hideki Kandori, Satoshi P. Tsunoda   +3 more
doaj   +1 more source