Results 111 to 120 of about 18,484 (195)

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain. [PDF]

, 2015
© 2015 The Authors.Objective: Although Glucagon-like peptide 1 is a key regulator of energy metabolism and food intake, the precise location of GLP-1 receptors and the physiological relevance of certain populations is debatable.
Cork, SC, Gribble, FM, Holt, MK, Reimann, F, Richards, JE, Trapp, S   +5 more
core   +2 more sources

Design and Implementation of a Simulation Framework for a Bio–Neural Dust System

Modelling
This paper presents the development of a computer simulation framework, designed as a cost–effective and technically efficient alternative to experimental studies.
Oussama Abderrahmane Dambri, Arash Azarnoush, Dimitrios Makrakis, Gabriel Levesque, Maja Witter, Abdelhakim Senhaji Hafid   +5 more
doaj   +1 more source

Optogenetic Evocation of Field Inhibitory Postsynaptic Potentials in Hippocampal Slices: A Simple and Reliable Approach for Studying Pharmacological Effects on GABAA and GABAB Receptor-Mediated Neurotransmission

Frontiers in Cellular Neuroscience, 2014
The GABAergic system is the main source of inhibition in the mammalian brain. Consequently, much effort is still made to develop new modulators of GABAergic synaptic transmission.
Julien eDine, Claudia eKühne, Jan M Deussing, Matthias eEder   +3 more
doaj   +1 more source

Gap junctional and ephaptic coupling in cardiac electrical propagation: homocellular and heterocellular perspectives

The Journal of Physiology, EarlyView.
Abstract figure legend Intricate cellular electrical coupling networks in the heart. Various cell types couple the central cardiomyocyte through gap junctional contacts, with the exception of neurons. Whether ephaptic coupling (EpC) occurs in homocellular or heterocellular contexts beyond cardiomyocyte–cardiomyocyte interactions remains unclear ...
Xiaobo Wu, Laura Beth Payne, Robert G. Gourdie   +2 more
wiley   +1 more source

Neuromodulation: present and emerging methods. [PDF]

, 2014
Neuromodulation has wide ranging potential applications in replacing impaired neural function (prosthetics), as a novel form of medical treatment (therapy), and as a tool for investigating neurons and neural function (research).
Constandinou, TG, Luan, S, Nikolic, K, Williams, I   +3 more
core   +1 more source

Multidimensional screening yields channelrhodopsin variants having improved photocurrent and order-of-magnitude reductions in calcium and proton currents

Journal of Biological Chemistry, 2019
Channelrhodopsins (ChRs) are light-gated ion channels in widespread use in neuroscience for mediating the genetically targetable optical control of neurons (optogenetics).
Y. Cho, Demian Park, A. Yang, Fei Chen, A. Chuong, Nathan C. Klapoetke, E. Boyden   +6 more
semanticscholar   +1 more source

Optogenetic Pacing: Current Insights and Future Potential

Research Reports in Clinical Cardiology, 2020
Airong Li, Rudolph E Tanzi Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USACorrespondence: Airong Li; Rudolph E TanziGenetics and Aging Research Unit, Department of
Li A, Tanzi RE
doaj  

Evaluating the outcomes of pluripotent stem‐cell‐derived photoreceptor transplantation in retinal repair

The FEBS Journal, Volume 292, Issue 21, Page 5567-5579, November 2025.
Transplantation of stem cell‐derived photoreceptors in retinal repair. We summarize methods for differentiating stem cells and describe surgical techniques for transplanting photoreceptor precursors to restore visual function (A). The effectiveness of these techniques is assessed with behavioral (B) and in vitro assays (C) using mouse models that mimic
Darin Zerti, Birthe Dorgau, Evelyne Sernagor, Lyle Armstrong, Majlinda Lako, Gerrit Hilgen   +5 more
wiley   +1 more source

Cellular resolution circuit mapping with temporal-focused excitation of soma-targeted channelrhodopsin

eLife, 2016
We describe refinements in optogenetic methods for circuit mapping that enable measurements of functional synaptic connectivity with single-neuron resolution.
Christopher A. Baker, Yishai M. Elyada, Andres Parra, M. Bolton   +3 more
semanticscholar   +1 more source

Organization of Valence-Encoding and Projection-Defined Neurons in the Basolateral Amygdala

Cell Reports, 2018
The basolateral amygdala (BLA) mediates associative learning for both fear and reward. Accumulating evidence supports the notion that different BLA projections distinctly alter motivated behavior, including projections to the nucleus accumbens (NAc ...
Anna Beyeler, Chia-Jung Chang, Margaux Silvestre, Clémentine Lévêque, Praneeth Namburi, Craig P. Wildes, Kay M. Tye   +6 more
doaj   +1 more source