Results 121 to 130 of about 18,335 (296)
Exploring adult hippocampal neurogenesis using optogenetics [PDF]
, 2018 In the 1980s, it was widely accepted that new neurons are continuously generated in the dentate gyrus of the mammalian hippocampus. Since its acceptance, researchers have employed various techniques and behavioral paradigms to study the proliferation ...
Pinardo, Heinrich
core
wavelength dependent photoreactions induced by ground-state heterogeneity [PDF]
, 2015 The primary photodynamics of channelrhodopsin-1 from Chlamydomonas augustae (CaChR1) was investigated by VIS-pump supercontinuum probe experiments from femtoseconds to 100 picoseconds.
Heberle, Joachim +4 more
core +1 more source
Optogenetic inhibition of behavior with anion channelrhodopsins [PDF]
Nature Methods, 2017 Optogenetics uses light exposure to manipulate physiology in genetically modified organisms. Abundant tools for optogenetic excitation are available, but the limitations of current optogenetic inhibitors present an obstacle to demonstrating the necessity of neuronal circuits.
Tong-Wey Koh +8 more
openaire +3 more sources
Epilepsia, EarlyView.Abstract The cerebellum, a subcortical structure, is traditionally linked to sensorimotor integration and coordination, although its role in cognition and affective behavior, as well as epilepsy, is increasingly recognized. Cerebellar dysfunction in patients with epilepsy can result from genetic disorders, antiseizure medications, seizures, and seizure‐
Christopher Elder +4 more
wiley +1 more source
Continuous Dynamic Photostimulation - inducing in-vivo-like fluctuating conductances with Channelrhodopsins [PDF]
arXiv, 2013 Central neurons operate in a regime of constantly fluctuating conductances, induced by thousands of presynaptic cells. Channelrhodopsins have been almost exclusively used to imprint a fixed spike pattern by sequences of brief depolarizations. Here we introduce continuous dynamic photostimulation (CoDyPs), a novel approach to mimic in-vivo like input ...
arxiv
Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis. [PDF]
, 2020 Cold stimuli and the subsequent activation of β-adrenergic receptor (β-AR) potently stimulate adipose tissue thermogenesis and increase whole-body energy expenditure.
Ferro, Marc D +8 more
core
structure and mechanism of a light-gated cation channel [PDF]
, 2014 The new and vibrant field of optogenetics was founded by the seminal discovery of channelrhodopsin, the first light-gated cation channel. Despite the numerous applications that have revolutionised neurophysiology, the functional mechanism is far from ...
Heberle, Joachim +1 more
core +1 more source
Opening Ion-Transfer Paths of Channelrhodopsin [PDF]
Biophysical Journal, 2016 The light-driven reaction cycle of channelrhodopsin involves coupling between proton-transfer reactions, water and protein dynamics. In the resting state of the channel, the retinal chromophore is all-trans and the ion-conducting channel is closed. Upon photoisomerization of the retinal to 13-cis, a reaction cycle is triggered during which a cation ...
Joachim Heberle +2 more
openaire +2 more sources
Optogenetically‐induced sustained hypothalamic hyperexcitability impairs memory via thalamic spread
Epilepsia, EarlyView.Abstract Objective Clinical investigators have hypothesized that interictal epileptiform discharges (IEDs) generated by hypothalamic hamartoma (HH) lead to cognitive dysfunction in patients with drug‐resistant gelastic seizures. Herein we provide causal evidence supporting this hypothesis by demonstrating that excitatory neural bursts, when propagating
Masaki Sonoda +11 more
wiley +1 more source
Neurogastroenterology &Motility, EarlyView.In vitro studies with GI surgical specimens or biopsy are a critical step in translating preclinical studies in animals to humans before testing potential therapeutic interventions in expensive clinical trials. Routine availability of human gut specimens, in combination with technological advances and powerful new in vitro models of the human ENS from ...
Dmitrii Pavlov, Fievos L. Christofi
wiley +1 more source