Results 121 to 130 of about 18,484 (195)

Regulated peristalsis into the acidic region of the _Drosophila_ larval midgut is controlled by a novel component of the Autonomic Nervous System [PDF]

open access: yes, 2009
The underlying cellular and molecular mechanisms that regulate and coordinate critical physiological processes such as peristalsis are complex, often cryptic, and involve the integration of multiple tissues and organ systems within the organism.
Brooke Ann Johnson   +4 more
core   +1 more source

Channelrhodopsin fluorescent tag replacement for clinical translation of optogenetic hearing restoration.

open access: yesMolecular Therapy: Methods & Clinical Development, 2023
Maria Zerche   +4 more
semanticscholar   +1 more source

Nonadiabatic Photodynamics of Retinal Protonated Schiff Base in Channelrhodopsin 2.

open access: yesJournal of Physical Chemistry Letters, 2019
Channelrhodopsin 2 (ChR2) is a light-gated ion channel and an important tool in optogenetics. Photoisomerization of retinal protonated Schiff base (RPSB) in ChR2 triggers channel activation.
Ruibin Liang, Fang Liu, T. Martínez
semanticscholar   +1 more source

Optogenetic dissection of neuronal circuits in zebrafish using viral gene transfer and the Tet system

open access: yesFrontiers in Neural Circuits, 2009
The conditional expression of transgenes at high levels in sparse and specific populations of neurons is important for high-resolution optogenetic analyses of neuronal circuits.
Peixin Zhu   +14 more
doaj   +1 more source

Cell type-specific and time-dependent light exposure contribute to silencing in neurons expressing Channelrhodopsin-2

open access: yeseLife, 2014
Channelrhodopsin-2 (ChR2) has quickly gained popularity as a powerful tool for eliciting genetically targeted neuronal activation. However, little has been reported on the response kinetics of optogenetic stimulation across different neuronal subtypes ...
Alexander M Herman   +4 more
doaj   +1 more source

Activation of Distinct Channelrhodopsin Variants Engages Different Patterns of Network Activity

open access: yeseNeuro, 2019
Several recently developed Channelrhodopsin (ChR) variants are characterized by rapid kinetics and reduced desensitization in comparison to the widely used ChR2.
Na Young Jun, Jessica A. Cardin
semanticscholar   +1 more source

Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine

open access: yesCell, 2021
K. Kishi   +24 more
semanticscholar   +1 more source

Crystal structure of a natural light-gated anion channelrhodopsin

open access: yesbioRxiv, 2018
The anion channelrhodopsin GtACR1 from the alga Guillardia theta is a potent neuron-inhibiting optogenetics tool. Presented here, its X-ray structure at 2.9 Å reveals a tunnel traversing the protein from its extracellular surface to a large cytoplasmic ...
Hai Li   +7 more
semanticscholar   +1 more source

In vivo large-scale cortical mapping using channelrhodopsin-2 stimulation in transgenic mice reveals asymmetric and reciprocal relationships between cortical areas

open access: yesFrontiers in Neural Circuits, 2012
We have mapped intracortical activity in vivo independent of sensory input using arbitrary point channelrhodopsin-2 (ChR2) stimulation and regional voltage sensitive dye imaging in B6.Cg-Tg (Thy1-COP4/EYFP)18Gfng/J transgenic mice.
Diana H Lim   +8 more
doaj   +1 more source

Time-resolved infrared spectroscopic techniques as applied to Channelrhodopsin

open access: yesFrontiers in Molecular Biosciences, 2015
Among optogenetic tools, channelrhodopsins, the light gated ion channels of the plasma membrane from green algae, play the most important role. Properties like channel selectivity, timing parameters or color can be influenced by the exchange of selected ...
Eglof eRitter   +6 more
doaj   +1 more source

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