Results 11 to 20 of about 18,484 (195)

Ion Channel Properties of a Cation Channelrhodopsin, Gt_CCR4

Applied Sciences, 2019
We previously reported a cation channelrhodopsin, Gt_CCR4, which is one of the 44 types of microbial rhodopsins from a cryptophyte flagellate, Guillardia theta.
Shunta Shigemura, S. Hososhima, H. Kandori, S. Tsunoda   +3 more
semanticscholar   +3 more sources

Structures of channelrhodopsin paralogs in peptidiscs explain their contrasting K+ and Na+ selectivities

Nature Communications, 2023
Kalium channelrhodopsin 1 from Hyphochytrium catenoides (HcKCR1) is a light-gated channel used for optogenetic silencing of mammalian neurons. It selects K+ over Na+ in the absence of the canonical tetrameric K+ selectivity filter found universally in ...
T. Morizumi, Kyumhyuk Kim, Hai Li, E. Govorunova, O. Sineshchekov, Yumei Wang, Lei Zheng, É. Bertalan, A. Bondar, Azam Askari, L. Brown, J. Spudich, O. Ernst   +12 more
semanticscholar   +1 more source

Optogenetic control of medaka behavior with channelrhodopsin

bioRxiv, 2023
Optogenetics enables the manipulation of neural activity with high spatiotemporal resolution in genetically defined neurons. The method is widely used in various model animals in the neuroscience and physiology fields.
Takahide Seki, H. Takeuchi, Satoshi Ansai   +2 more
semanticscholar   +1 more source

A blue-shifted anion channelrhodopsin from the Colpodellida alga Vitrella brassicaformis

Scientific Reports, 2023
Microbial rhodopsins, a family of photoreceptive membrane proteins containing the chromophore retinal, show a variety of light-dependent molecular functions.
Keiichi Kojima, Shiho Kawanishi, Y. Nishimura, Masumi Hasegawa, Shin Nakao, Yuya Nagata, Susumu Yoshizawa, Yuki Sudo   +7 more
semanticscholar   +1 more source

Coupling the Cardiac Voltage-Gated Sodium Channel to Channelrhodopsin-2 Generates Novel Optical Switches for Action Potential Studies

Membranes, 2022
Voltage-gated sodium (Na+) channels respond to short membrane depolarization with conformational changes leading to pore opening, Na+ influx, and action potential (AP) upstroke.
Christian vom Dahl, Christoph Emanuel Müller, Xhevat Berisha, Georg Nagel, Thomas Zimmer   +4 more
doaj   +1 more source

WiChR, a highly potassium-selective channelrhodopsin for low-light one- and two-photon inhibition of excitable cells

Science Advances, 2022
The electric excitability of muscle, heart, and brain tissue relies on the precise interplay of Na+- and K+-selective ion channels. The involved ion fluxes are controlled in optogenetic studies using light-gated channelrhodopsins (ChRs).
J. Vierock, Enrico Peter, C. Grimm, Andrey Rozenberg, I-Wen Chen, Linda Tillert, Alejandro G. Castro Scalise, M. Casini, Sandra Augustin, Dimitrii Tanese, Benoît C Forget, R. Peyronnet, F. Schneider-Warme, V. Emiliani, O. Béjà, P. Hegemann   +15 more
semanticscholar   +1 more source

Bimodal activation of different neuron classes with the spectrally red-shifted channelrhodopsin chimera C1V1 in Caenorhabditis elegans [PDF]

, 2012
The C. elegans nervous system is particularly well suited for optogenetic analyses of circuit function: Essentially all connections have been mapped, and light can be directed at the neuron of interest in the freely moving, transparent animals, while ...
Erbguth, Karen, Gottschalk, Alexander, Hegemann, Peter, Prigge, Matthias, Schneider, Franziska   +4 more
core   +6 more sources

Visual function restoration with a highly sensitive and fast Channelrhodopsin in blind mice

Signal Transduction and Targeted Therapy, 2022
progressive loss of photoreceptors, ultimately leading to blind- ness. Optogenetics is a promising strategy for restoring visual function through photosensitive proteins ’ ectopic expression in surviving retinal neurons.
Fei Chen, Xiaodong Duan, Yao Yu, Shang Yang, Yuanyuan Chen, C. Gee, G. Nagel, Kang Zhang, Shiqiang Gao, Yin Shen   +9 more
semanticscholar   +1 more source

Aion is a bistable anion-conducting channelrhodopsin that provides temporally extended and reversible neuronal silencing

Communications Biology, 2022
Optogenetic silencing allows to reveal the necessity of selected neuronal populations for various neurophysiological functions. These range from synaptic transmission and coordinated neuronal network activity to control of specific behaviors.
S. Rodriguez-Rozada, Jonas Wietek, F. Tenedini, K. Sauter, Neena Dhiman, P. Hegemann, P. Soba, J. Simon Wiegert   +7 more
semanticscholar   +1 more source

Optogenetic restoration of high sensitivity vision with bReaChES, a red-shifted channelrhodopsin

Scientific Reports, 2022
The common final pathway to blindness in many forms of retinal degeneration is the death of the light-sensitive primary retinal neurons. However, the normally light-insensitive second- and third-order neurons persist optogenetic gene therapy aims to ...
L. K. Too, Weiyong Shen, D. Protti, Atomu Sawatari, Dylan A. Black, C. Leamey, Jin Y. Huang, Sora Lee, Ashish E. Mathai, L. Lisowski, John Y. Lin, Mark C. Gillies, M. Simunovic   +12 more
semanticscholar   +1 more source