Results 21 to 30 of about 17,118 (247)
Structural Model of Channelrhodopsin [PDF]
Journal of Biological Chemistry, 2012 Channelrhodopsins (ChRs) are light-gated cation channels that mediate ion transport across membranes in microalgae (vectorial catalysis). ChRs are now widely used for the analysis of neural networks in tissues and living animals with light (optogenetics).
Watanabe, H. C. +7 more
openaire +3 more sources
Frontiers in Molecular Biosciences, 2022 The translocon-unassisted folding process of transmembrane domains of the microbial rhodopsins sensory rhodopsin I (HsSRI) and II (HsSRII), channelrhodopsin II (CrChR2), and bacteriorhodopsin (HsBR) during cell-free expression has been investigated by ...
Kenichi Ataka +5 more
doaj +1 more source
Non-viral delivery and optimized optogenetic stimulation of retinal ganglion cells led to behavioral restoration of vision [PDF]
, 2012 Stimulation of retinal neurons using optogenetics via use of chanelrhodopsin-2 (ChR2) has opened up a new direction for restoration of vision for treatment of retinitis pigmentosa (RP).
Edward Wong +5 more
core +2 more sources
Functional cardiac imaging by random access microscopy
Frontiers in Physiology, 2014 Advances in the development of voltage sensitive dyes and Ca2+ sensors in combination with innovative microscopy techniques allowed researchers to perform functional measurements with an unprecedented spatial and temporal resolution.
Claudia eCrocini +7 more
doaj +1 more source
Fast targeted gene transfection and optogenetic modification of single neurons using femtosecond laser irradiation [PDF]
, 2013 This work is supported by the UK Engineering Physical Sciences Research Council (EPSRC).A prevailing problem in neuroscience is the fast and targeted delivery of DNA into selected neurons.
Antkowiak, Maciej +5 more
core +1 more source
Biophysical properties of optogenetic tools and their application for vision restoration approaches.
Frontiers in Systems Neuroscience, 2016 Optogenetics is the use of genetically encoded light-activated proteins to manipulate cells in a minimally invasive way using light. The most prominent example is channelrhodopsin2 (ChR2), which allows the activation of electrically excitable cells via ...
Simon Darius Klapper +3 more
doaj +1 more source
Utility of red‐light ultrafast optogenetic stimulation of the auditory pathway
EMBO Molecular Medicine, 2021 Optogenetic stimulation of spiral ganglion neurons (SGNs) in the ear provides a future alternative to electrical stimulation used in current cochlear implants. Here, we employed fast and very fast variants of the red‐light‐activated channelrhodopsin (ChR)
Burak Bali +6 more
doaj +1 more source
Frontiers in Systems Neuroscience, 2018 Quantitative analysis of corticocortical signaling is needed to understand and model information processing in cerebral networks. However, higher-order pathways, hodologically remote from sensory input, are not amenable to spatiotemporally precise ...
Xiaojian Li +6 more
doaj +1 more source
Active avoidance requires inhibitory signaling in the rodent prelimbic prefrontal cortex
eLife, 2018 Much is known about the neural circuits of conditioned fear and its relevance to understanding anxiety disorders, but less is known about other anxiety-related behaviors such as active avoidance.
Maria M Diehl +6 more
doaj +1 more source
Dampening Spontaneous Activity Improves the Light Sensitivity and Spatial Acuity of Optogenetic Retinal Prosthetic Responses [PDF]
, 2016 Retinitis pigmentosa is a progressive retinal dystrophy that causes irreversible visual impairment and blindness. Retinal prostheses currently represent the only clinically available vision-restoring treatment, but the quality of vision returned remains ...
Barrett, John Martin +2 more
core +1 more source