Results 21 to 30 of about 18,335 (296)
Nature Communications, 2023 Kalium channelrhodopsin 1 from Hyphochytrium catenoides (HcKCR1) is a light-gated channel used for optogenetic silencing of mammalian neurons. It selects K+ over Na+ in the absence of the canonical tetrameric K+ selectivity filter found universally in ...
T. Morizumi +12 more
semanticscholar +1 more source
Anion channelrhodopsins for inhibitory cardiac optogenetics [PDF]
Scientific Reports, 2016 AbstractOptical control of the heart muscle is a promising strategy for cardiology because it is more specific than traditional electrical stimulation, and allows a higher temporal resolution than pharmacological interventions. Anion channelrhodopsins (ACRs) from cryptophyte algae expressed in cultured neonatal rat ventricular cardiomyocytes produced ...
Elena G. Govorunova +3 more
openalex +3 more sources
Potassium-selective channelrhodopsins
Biophysics and Physicobiology, 2023 Since their discovery 21 years ago, channelrhodopsins have come of age and have become indispensable tools for optogenetic control of excitable cells such as neurons and myocytes. Potential therapeutic utility of channelrhodopsins has been proven by partial vision restoration in a human patient.
Elena G. Govorunova +2 more
openaire +4 more sources
Transmitting FRET signals to nerve cells [PDF]
5th ACM/IEEE International Conference on Nanoscale Computing and
Communication, September 2018, 2021 This paper is concerned with a novel method allowing communication between FRET nanonetworks and nerve cells. It is focused on two system components: fluorophores and channelrhodopsins which serve as transmitters and receivers, respectively. Channelrhodopsins are used here also as a FRET signal-to-voltage converter. The trade-off between throughput and
arxiv +1 more source
Science Advances, 2022 The electric excitability of muscle, heart, and brain tissue relies on the precise interplay of Na+- and K+-selective ion channels. The involved ion fluxes are controlled in optogenetic studies using light-gated channelrhodopsins (ChRs).
J. Vierock +15 more
semanticscholar +1 more source
Visual function restoration with a highly sensitive and fast Channelrhodopsin in blind mice
Signal Transduction and Targeted Therapy, 2022 progressive loss of photoreceptors, ultimately leading to blind- ness. Optogenetics is a promising strategy for restoring visual function through photosensitive proteins ’ ectopic expression in surviving retinal neurons.
Fei Chen +9 more
semanticscholar +1 more source
Hemodynamic responses evoked by neuronal stimulation via channelrhodopsin-2 can be independent of intracortical glutamatergic synaptic transmission. [PDF]
PLoS ONE, 2012 Maintenance of neuronal function depends on the delivery of oxygen and glucose through changes in blood flow that are linked to the level of ongoing neuronal and glial activity, yet the underlying mechanisms remain unclear.
Nadia A Scott, Timothy H Murphy
doaj +1 more source
Communications Biology, 2022 Optogenetic silencing allows to reveal the necessity of selected neuronal populations for various neurophysiological functions. These range from synaptic transmission and coordinated neuronal network activity to control of specific behaviors.
S. Rodriguez-Rozada +7 more
semanticscholar +1 more source
Bimodal activation of different neuron classes with the spectrally red-shifted channelrhodopsin chimera C1V1 in Caenorhabditis elegans [PDF]
, 2012 The C. elegans nervous system is particularly well suited for optogenetic analyses of circuit function: Essentially all connections have been mapped, and light can be directed at the neuron of interest in the freely moving, transparent animals, while ...
Erbguth, Karen +4 more
core +5 more sources
Membranes, 2022 Voltage-gated sodium (Na+) channels respond to short membrane depolarization with conformational changes leading to pore opening, Na+ influx, and action potential (AP) upstroke.
Christian vom Dahl +4 more
doaj +1 more source