Results 71 to 80 of about 18,335 (296)
Timing Control of Single Neuron Spikes with Optogenetic Stimulation [PDF]
, 2018 This paper predicts the ability to externally control the firing times of a cortical neuron whose behavior follows the Izhikevich neuron model. The Izhikevich neuron model provides an efficient and biologically plausible method to track a cortical neuron'
Eckford, Andrew W. +3 more
core +2 more sources
Specificity, Versatility, and Continual Development: The Power of Optogenetics for Epilepsy Research
Frontiers in Cellular Neuroscience, 2018 Optogenetics is a powerful and rapidly expanding set of techniques that use genetically encoded light sensitive proteins such as opsins. Through the selective expression of these exogenous light-sensitive proteins, researchers gain the ability to ...
Zoé Christenson Wick +1 more
doaj +1 more source
Modeling Interference-Free Neuron Spikes with Optogenetic Stimulation [PDF]
, 2019 This paper predicts the ability to externally control the firing times of a cortical neuron whose behavior follows the Izhikevich neuron model. The Izhikevich neuron model provides an efficient and biologically plausible method to track a cortical neuron'
Eckford, Andrew W. +3 more
core +2 more sources
Reaction dynamics of the chimeric channelrhodopsin C1C2 [PDF]
Scientific Reports, 2017 AbstractChannelrhodopsin (ChR) is a key protein of the optogenetic toolkit. C1C2, a functional chimeric protein of Chlamydomonas reinhardtii ChR1 and ChR2, is the only ChR whose crystal structure has been solved, and thus uniquely suitable for structure-based analysis.
Marco Marazzi +9 more
openaire +7 more sources
The Polarizable Embedding Density Matrix Renormalization Group Method [PDF]
J. Chem. Theory Comput., 2016, 12 (9), pp 4242-4253, 2016 The polarizable embedding (PE) approach is a flexible embedding model where a pre-selected region out of a larger system is described quantum mechanically while the interaction with the surrounding environment is modeled through an effective operator.
arxiv +1 more source
Neuromodulation: present and emerging methods. [PDF]
, 2014 Neuromodulation has wide ranging potential applications in replacing impaired neural function (prosthetics), as a novel form of medical treatment (therapy), and as a tool for investigating neurons and neural function (research).
Constandinou, TG +3 more
core +1 more source
Diversity of Chlamydomonas Channelrhodopsins [PDF]
Photochemistry and Photobiology, 2011 AbstractChannelrhodopsins act as photoreceptors for control of motility behavior in flagellates and are widely used as genetically targeted tools to optically manipulate the membrane potential of specific cell populations (“optogenetics”). The first two channelrhodopsins were obtained from the model organism Chlamydomonas reinhardtii (CrChR1 and CrChR2)
Oleg A. Sineshchekov +6 more
openaire +3 more sources
Spatiotemporal Control of GPR37 Signaling and Its Behavioral Effects by Optogenetics
Frontiers in Molecular Neuroscience, 2018 Despite the progress in deorphanization of G Protein-Coupled Receptors (GPCRs), ≈100 GPCRs are still classified as orphan receptors without identified endogenous ligands and with unknown physiological functions.
Wu Zheng +20 more
doaj +1 more source
The clinical potential of optogenetic interrogation of pathogenesis
Clinical and Translational Medicine, 2023 Background Opsin‐based optogenetics has emerged as a powerful biomedical tool using light to control protein conformation. Such capacity has been initially demonstrated to control ion flow across the cell membrane, enabling precise control of action ...
Tianyu Terry Gao +8 more
doaj +1 more source
Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording
Micromachines, 2021 During the last decade, optogenetics has become an essential tool for neuroscience research due to its unrivaled feature of cell-type-specific neuromodulation. There have been several technological advances in light delivery devices.
Saeyeong Jeon +6 more
doaj +1 more source