Results 71 to 80 of about 17,118 (247)
Advanced Science, EarlyView.The Single‐Nanostructured Optoelectronic Vehicle for neuromodulation Activation (SNOVA) establishes a paradigm for non‐genetic, implant‐free neuromodulation. By integrating NIR‐excitable UCNPs with broadband‐absorbing perovskite QDs, SNOVA efficiently converts deeply penetrating light into localized electric fields that modulate neuronal ion dynamics ...
Luyue Jiang +19 more
wiley +1 more source
Gating mechanisms of a natural anion channelrhodopsin [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance The recently discovered natural anion channelrhodopsins (ACRs) have exceptional properties for use as membrane-hyperpolarizing tools for neural silencing, but our knowledge about them is only rudimentary. We have gained, to our knowledge, first insights into the molecular mechanisms of their unique light-gated anion conductance ...
Oleg A, Sineshchekov +3 more
openaire +2 more sources
Machine learning-guided directed evolution for protein engineering [PDF]
, 2019 Machine learning (ML)-guided directed evolution is a new paradigm for biological design that enables optimization of complex functions. ML methods use data to predict how sequence maps to function without requiring a detailed model of the underlying ...
Arnold, Frances H. +2 more
core +1 more source
Root Mean Square Error of Neural Spike Train Sequence Matching with Optogenetics
, 2017 Optogenetics is an emerging field of neuroscience where neurons are genetically modified to express light-sensitive receptors that enable external control over when the neurons fire.
Eckford, Andrew W. +2 more
core +1 more source
Recent advances in engineering microbial rhodopsins for optogenetics [PDF]
, 2015 Protein engineering of microbial rhodopsins has been successful in generating variants with improved properties for applications in optogenetics.
Arnold, Frances H. +2 more
core +1 more source
Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling
Advanced Science, EarlyView.Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu +20 more
wiley +1 more source
Frontiers in Aging Neuroscience, 2020 Brains depend on blood flow for the delivery of oxygen and nutrients essential for proper neuronal and synaptic functioning. French physiologist Rouget was the first to describe pericytes in 1873 as regularly arranged longitudinal amoeboid cells on ...
Amy R. Nelson +5 more
doaj +1 more source
wavelength dependent photoreactions induced by ground-state heterogeneity [PDF]
, 2015 The primary photodynamics of channelrhodopsin-1 from Chlamydomonas augustae (CaChR1) was investigated by VIS-pump supercontinuum probe experiments from femtoseconds to 100 picoseconds.
Heberle, Joachim +4 more
core +1 more source
Multimodal Layer‐Crossing Interrogation of Brain Circuits Enabled by Microfluidic Axialtrodes
Advanced Science, EarlyView.The study introduces a flexible microfluidic axialtrode that integrates optical, electrical, and chemical modalities within a single polymer fiber. By redistributing electrodes and fluidic channels along the fiber axis via angled cleaving, it enables simultaneous optogenetic stimulation, electrophysiological recording, and drug delivery across brain ...
Kunyang Sui +8 more
wiley +1 more source
Allatostatin-A neurons inhibit feeding behavior in adult Drosophila [PDF]
, 2012 How the brain translates changes in internal metabolic state or perceived food quality into alterations in feeding behavior remains poorly understood.
Anderson, David J. +2 more
core +2 more sources