Results 151 to 160 of about 226,086 (342)

Application of crystalline sponge method and crystallization chaperone technology in the structure elucidation of natural products [PDF]

Yuxin Kan, Yuxuan Zhang, Fujiang Guo, Yiming Li   +3 more
openalex   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Alpha-2-Macroglobulin, a Hypochlorite-Regulated Chaperone and Immune System Modulator [PDF]

, 2019
Jordan H. Cater, Mark R. Wilson, Amy R. Wyatt   +2 more
openalex   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Does Environmentally Contingent Variation in the Level of Molecular Chaperones Mirror a Biochemical Adaptation to Abiotic Stress?

, 2011
Branka Tucić, Sanja Jovanović, Ana Vulet   +2 more
openalex   +2 more sources

Protein folding while chaperone bound is dependent on weak interactions [PDF]

, 2019
Kevin Wu, Frederick Stull, Changhan Lee, James C.A. Bardwell   +3 more
openalex   +1 more source

Clinical Significance of Copper Chaperone for Superoxide Dismutase in Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Targeting Cu transport proteins is an innovative therapeutic approach for combating cancer. However, the mechanisms underlying the malignant potential of Cu transport proteins remain largely unknown. To address this issue, we focused on the oncogenic potential of copper chaperones for superoxide dismutase (CCS) in colorectal cancer (
Nobuo Takiguchi, Mamoru Uemura, Mao Osaki, Chikako Kusunoki, Masakatsu Paku, Mitsunobu Takeda, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe, Takayuki Ogino, Norikatsu Miyoshi, Mitsuyoshi Tei, Yoshinori Kagawa, Hirofumi Yamamoto, Yuichiro Doki, Hidetoshi Eguchi   +15 more
wiley   +1 more source

Alpha-crystallin can function as a molecular chaperone.

Proceedings of the National Academy of Sciences of the United States of America, 1992
J. Horwitz
semanticscholar   +1 more source

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

Faculty Opinions recommendation of Forces driving chaperone action.

, 2016
Tracy Raivio
openalex   +2 more sources