Results 241 to 250 of about 226,086 (342)

Chemical chaperones in metabolic fitness beyond protein folding [PDF]

Ester Zito, Alain Lescure, Nica Borgese
openalex   +1 more source

N‐Glycan‐based ER Molecular Chaperone and Protein Quality Control System: The Calnexin Binding Cycle

Traffic : the International Journal of Intracellular Transport, 2016
Lydia Lamriben, Jill B. Graham, Benjamin M. Adams, D. Hebert   +3 more
semanticscholar   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Probing the Coordination Environment of the Human Copper Chaperone HAH1: Characterization of Hg^II‐Bridged Homodimeric Species in Solution

, 2013
Marek Łuczkowski, Brian A. Zeider, Alia V. H. Hinz, Monika Stachura, Saumen Chakraborty, Lars Hemmingsen, David L. Huffman, Vincent L. Pecoraro   +7 more
openalex   +1 more source

Proteomic Changes in Cancer Cell Lines as a Result of Bacterial Infection

PROTEOMICS, EarlyView.
ABSTRACT Bacterial infections have been implicated in shaping the tumor microenvironment (TME), but their effects on cancer cell proteomes remain unexplored. In this study, we analyzed proteomic changes in melanoma (A375) and ovarian cancer (OVCAR3) cell line models following infection with Staphylococcus aureus strain USA300 or Salmonella enterica ...
Bo Ren, Kenneth Weke, Darryl Hardie, Mariya I. Goncheva, Ted Hupp, Javier Antonio Alfaro, Helena Pětrošová, David R. Goodlett   +7 more
wiley   +1 more source

Heat shock proteins in osteoarthritis: molecular mechanisms, pathogenic roles, and therapeutic opportunities. [PDF]

Front Immunol
Zhao B, Deng Z, Yang Z, Yang F, Yang W.
europepmc   +1 more source

Histone Chaperone NAP1 Mediates Sister Chromatid Resolution by Counteracting Protein Phosphatase 2A

, 2013
Yuri M. Moshkin, Cécile M. Doyen, Tsung Wai Kan, Gillian E. Chalkley, Karen A. Sap, Karel Bezstarosti, Jeroen Demmers, Zeliha Özgür, Wilfred F. J. van IJcken, C. Peter Verrijzer   +9 more
openalex   +2 more sources

Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent

Cell, 1997
C. E. Stebbins, A. Russo, C. Schneider, N. Rosen, F. Hartl, N. Pavletich   +5 more
semanticscholar   +1 more source

Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy

PROTEOMICS, EarlyView.
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling, Dounia Bouragba, Elisa Negroni, Capucine Trollet, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +6 more
wiley   +1 more source

Chaperone dependency during biogenesis does not correlate with chaperone dependency during refolding. [PDF]

Mol Syst Biol
Yadav D, Demiralp İI, Fakler M, Fried SD.   +3 more
europepmc   +1 more source