Modulating Chaperone-Mediated Autophagy and Its Clinical Applications in Cancer
Cells, 2022 Autophagy is a central mechanism for maintaining cellular homeostasis in health and disease as it provides the critical energy through the breakdown and recycling of cellular components and molecules within lysosomes.
Virginie Hubert +3 more
doaj +3 more sources
A Novel Chaperone-Based Cancer Vaccination Enhances Immunotherapeutic Responsiveness Through T Cell Amplification and Tumor Immune Remodeling [PDF]
VaccinesBackground/Objectives: Preclinical and clinical evidence supports a chaperone-based vaccination platform for cancer immunotherapy. The objective of this study is to interrogate the next generation of chaperone-based immune modulator, termed Flagrp170 ...
Xueqian Cheng +10 more
doaj +2 more sources
Targeting Hsp90 in Cancer for 25 Years: Failure of Previous Clinical Trials and New Hope for Future Therapeutics [PDF]
CellsAll previous IND (investigational new drug) applications to US FDA for launching clinical trials with Hsp90 ATP-binding inhibitors only provided a partial, if not misleading, account of the inhibitors’ actual MOA (mechanism of action).
Mei Chen +4 more
doaj +2 more sources
Presence of Chaperone during Pelvic Examination: Women’s Opinions and Preferences in a Tertiary Hospital in Abakaliki, Ebonyi State, Nigeria [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Pelvic examination in the evaluation of patients can be a source of dissatisfaction and litigation from patients. A chaperone is beneficial in militating against unforeseen circumstances surrounding this clinical examination.
Chidebe Christian Anikwe +6 more
doaj +1 more source
The effects of copper ion on cell proliferation and the clinical significance of copper ion in lung cancer [PDF]
Zhongguo aizheng zazhi, 2021 Background and purpose: Destroying the balance of copper ions in the body may promote the occurrence and development of cancer. This study aimed to investigate the effects of copper ion on cell proliferation and elucidate the clinical significance of ...
WU Ran , WANG Guizhen , CHENG Xin , ZHOU Guangbiao
doaj +1 more source
Co-crystalization and in vitro biological characterization of 5-Aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors [PDF]
, 2012 A potential therapeutic strategy for targeting cancer that has gained much interest is the inhibition of the ATP binding and ATPase activity of the molecular chaperone Hsp90.
Chrisostomos Prodromou +7 more
core +11 more sources
Extracellular Heat Shock Protein-90 (eHsp90): Everything You Need to Know
Biomolecules, 2022 “Extracellular” Heat Shock Protein-90 (Hsp90) was initially reported in the 1970s but was not formally recognized until 2008 at the 4th International Conference on The Hsp90 Chaperone Machine (Monastery Seeon, Germany).
Daniel Jay, Yongzhang Luo, Wei Li
doaj +1 more source
DNAJB6-Containing Extracellular Vesicles as Chaperone Delivery Systems: A Proteomic Analysis
Pharmaceutics, 2022 Cell-derived extracellular vesicles (EVs) are effectors of cell-to-cell communication that are in the spotlight as promising candidates for in vivo drug delivery because of their ability to enter cells and deliver cargo. For example, proteins of interest
Bhagyashree S. Joshi +4 more
doaj +1 more source
Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum [PDF]
, 2008 The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER).
Argent +32 more
core +4 more sources
Current Issues in Molecular Biology, 2023 Autosomal recessive spastic ataxia in Charlevoix-Saguenay (ARSACS) is a neurodegenerative disorder caused by mutations in the sacsin molecular chaperone protein (SACS) gene. Since the first report from Quebec in 1978, many pathogenic ARSACS variants with
Danyeong Kim +5 more
doaj +1 more source