Results 11 to 20 of about 129,105 (287)

Activation of sigma-1 receptor chaperone in the treatment of neuropsychiatric diseases and its clinical implication

Journal of Pharmacological Sciences, 2015
Endoplasmic reticulum (ER) protein sigma-1 receptor represents unique chaperone activity in the central nervous system, and it exerts a potent influence on a number of neurotransmitter systems. Several lines of evidence suggest that activation of sigma-1
Kenji Hashimoto
doaj   +3 more sources

Clinical Significance of Copper Chaperone for Superoxide Dismutase in Colorectal Cancer

Annals of Gastroenterological Surgery
ABSTRACTBackgroundTargeting Cu transport proteins is an innovative therapeutic approach for combating cancer. However, the mechanisms underlying the malignant potential of Cu transport proteins remain largely unknown. To address this issue, we focused on the oncogenic potential of copper chaperones for superoxide dismutase (CCS) in colorectal cancer ...
Nobuo Takiguchi, Mamoru Uemura, Mao Osaki, Chikako Kusunoki, Masakatsu Paku, Mitsunobu Takeda, Yuki Sekido, Tsuyoshi Hata, Atsushi Hamabe, Takayuki Ogino, Norikatsu Miyoshi, Mitsuyoshi Tei, Yoshinori Kagawa, Hirofumi Yamamoto, Yuichiro Doki, Hidetoshi Eguchi   +15 more
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Chaperoning in genitourinary medicine clinics [PDF]

Sexually Transmitted Infections, 2003
The Joint Specialty Committee for Genitourinary Medicine of the Royal College of Physicians has produced guidance on chaperoning in response to the General Medical Council (GMC) guidance on doctors performing intimate examinations.1 The definition of intimate examinations includes examination of the breasts, genitalia, or rectum.
R, Miller, K, Jones, D, Daniels, G, Forster, M G, Brook   +4 more
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Documentation of chaperone presence in breast clinic, a complete audit cycle [PDF]

Irish Journal of Medical Science (1971 -), 2021
Abstract Objective The General Medical Council (GMC) and Irish Medical Council (IMC) recommend the presence of a chaperone for all intimate examinations and that it should be clearly documented. The aim of this report is to assess doctors’ compliance with obtaining a chaperone and documenting their presence, determining ...
Aqeel Alameer, Amira Mohammed, Sami Abd Elwahab, Michael Boland, Amr Elfadul, Tej Tiwary, Colm Power, Michael Allen, Abeeda Butt, Arnold Hill   +9 more
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315 Chaperone Documentation in The Breast Clinic: A Closed Loop Audit [PDF]

British Journal of Surgery, 2021
Abstract Aim Intimate examinations are potentially uncomfortable and embarrassing. In addition to offering chaperones routinely, it is also important to clearly document the circumstances, with implications on patient dignity and safeguarding both patients and staff. We aimed to analyse the quality of
C Maden, A Lee, M l Kelly, Y R Im, M Barkeji   +4 more
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Mitochondrial chaperones in cancer: From molecular biology to clinical diagnostics [PDF]

Cancer Biology & Therapy, 2006
Mitochondria are cell organelles involved in processes of cell life and death, and therefore also in tumoral transformation. Indeed, mitochondria dysfunction is a prominent feature of cancer cells. Mitochondrial proteins and DNA have also been previously studied as markers of tumorigenesis.
CZARNECKA AM, CAMPANELLA, Claudia, ZUMMO, Giovanni, CAPPELLO, Francesco   +3 more
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Parkinson’s Disease-Specific Autoantibodies against the Neuroprotective Co-Chaperone STIP1

Cells, 2022
Parkinson’s disease (PD) is a debilitating movement disorder characterised by the loss of dopaminergic neurons in the substantia nigra. As neuroprotective agents mitigating the rate of neurodegeneration are unavailable, the current therapies largely ...
Jolene Su Yi Tan, Bernett Lee, Jackwee Lim, Dong Rui Ma, Jia Xin Goh, Suh Yee Goh, Muhammad Yaaseen Gulam, Ser Mei Koh, Weiling Wendy Lee, Lei Feng, Qing Wang, Yinxia Chao, Olaf Rötzschke, Eng King Tan   +13 more
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MP23-07 PATIENT PREFERENCE REGARDING CHAPERONE USE IN THE OUTPATIENT UROLOGY CLINIC [PDF]

Journal of Urology, 2021
INTRODUCTION AND OBJECTIVE:Chaperones are often employed during sensitive patient encounters and have been assumed to be mutually beneficial to the patient and provider.
Muneeb Alam, Moben Mirza, Jeffrey Thompson, Casey Kowalik   +3 more
openaire   +1 more source

Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery

Journal of Hematology & Oncology, 2018
Heat shock protein 90 (Hsp90) is a critical molecular chaperone protein that regulates the folding, maturation, and stability of a wide variety of proteins.
Ting Li, Hu-Lin Jiang, Yun-Guang Tong, Jin-Jian Lu   +3 more
doaj   +1 more source

The Financial Considerations of Employing a Dedicated Chaperone in Clinical Practice

Plastic Surgery, 2022
Introduction: Medical associations and medicolegal bodies are urging for increased chaperone use by physicians during intimate physical examinations in clinical practice (such as breast or pelvic examinations). However, widespread chaperone use is limited by factors such as staff availability and financial considerations ...
Nick N Maizlin, Stephanie Black, Olubimpe Ayeni   +2 more
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