Results 211 to 220 of about 129,105 (287)

Heat stress alters metabolic pathways and nitric oxide signaling in keratinocytes under hyperglycemia

Journal of Diabetes Investigation, EarlyView.
This illustration depicts the effects of thermal stress on human keratinocytes maintained in both normal and high‐glucose conditions. Under normal glucose conditions, heat exposure enhances arginine metabolism and increases nitric oxide (NO) production, which promotes alterations in mitochondrial morphology and elevates heat shock protein 70 (Hsp70 ...
Syeda Tayyiba Rahat, Ilkka Miinalainen, Anni I. Nieminen, Seppo Vainio, Nsrein Ali   +4 more
wiley   +1 more source

Proteome-Wide Mapping of Artesunate Targets Reveals Enrichment of the Ubiquitin-Proteasome System. [PDF]

Drug Des Devel Ther
Wang G, Tang X, Zhang F.
europepmc   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Therapeutic targets in diabetic peripheral neuropathy: heat shock proteins. [PDF]

Front Endocrinol (Lausanne)
Yin C, Lv J, Huang S, Lang C, Zhao Y, Wang G, Kan J, Wang X.   +7 more
europepmc   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

The TRiC/CCT Complex at the Crossroads of Metabolism and Hypoxia in GBM: Implications for IDH-Dependent Therapeutic Targeting. [PDF]

Int J Mol Sci
Alberti G, D'Amico G, Augello MA, Cappello F, Szychlinska MA, Caruso Bavisotto C, Scalia F.   +6 more
europepmc   +1 more source

Tumor suppressor Tsc1 is a new Hsp90 co‐chaperone that facilitates folding of kinase and non‐kinase clients [PDF]

, 2017
et al,, Gutmann, David H, Rensing, Nicholas, Wong, Michael   +3 more
core   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

The gram-positive HtrA, the protease that is also a chaperone. [PDF]

J Bacteriol
Latimer S, Agbavor C, Cahoon LA.
europepmc   +1 more source