Results 31 to 40 of about 129,105 (287)

Inhibition of HSP90 molecular chaperones: moving into the clinic

The Lancet Oncology, 2013
Heat shock protein 90 (HSP90) is a molecular chaperone that is crucial for the stability and function of many proteins essential for cell survival. Many oncogenes, including tyrosine kinases, transcription factors, and cell-cycle regulatory proteins, are client proteins of HSP90.
García-Carbonero, Rocío, Carnero, Amancio, Paz-Ares, Luis   +2 more
openaire   +3 more sources

The metal chaperone protein MtmA plays important roles in antifungal drug susceptibility in Aspergillus fumigatus

Frontiers in Microbiology, 2022
Drug-resistant fungal infections are emerging as an important clinical problem. In general, antifungal resistance results from increased target expression or mutations within the target protein sequence.
Pengfei Zhai, Yinyan Ma, Wenlong Du, Ling Lu   +3 more
doaj   +1 more source

The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog [PDF]

, 2014
Chronic spinal cord dysfunction occurs in dogs as a consequence of diverse aetiologies, including long-standing spinal cord compression and insidious neurodegenerative conditions. One such neurodegenerative condition is canine degenerative myelopathy (DM)
A Brodbelt, A Felbecker, AM Lidstrom, AM Lidstrom, AM Nilselid, B Szoor, C Sihlbom, C Wang, DR Averill, EM Schrijvers, FA Wininger, GB Cherubini, GD Shelton, H Reiber, H Satoh, H Tumani, Intan N. F. Shafie, IR Griffiths, Jacques Penderis, JR Coates, JW Harvey, K Al-Saktawi, K Sasaki, L Klimaschewski, M Calero, MA Stoodley, Mark McLaughlin, Mary Ann A. Lim, O Cordero-Llana, P Montague, P Narayan, PA March, Pamela E. J. Johnston, Paul Montague, PEJ Johnston, Richard Burchmore, RP Grewal, SE Jones, T Awano, Thomas J. Anderson   +39 more
core   +1 more source

The Use of Chaperones in Clinical Practice

Korean Journal of Medical Ethics, 2010
Personal relationships between doctors and patients are essential for effective treatment. Optimal care is possible only when there is trust between the doctor and patient. In recent years, disputes between healthcare providers and patients have been increasing.
Han-Nah Kim, Yoonhyung Park
openaire   +1 more source

Exploring the translational potential of clusterin as a biomarker of early osteoarthritis

Journal of Orthopaedic Translation, 2022
Background: Clusterin (CLU; also known as apolipoprotein J) is an ATP-independent holdase chaperone that prevents proteotoxicity as a consequence of protein aggregation.
Ursule Kalvaityte, Csaba Matta, Eiva Bernotiene, Peter Natesan Pushparaj, Ata M. Kiapour, Ali Mobasheri   +5 more
doaj   +1 more source

Could Upregulated Hsp70 Protein Compensate for the Hsp90-Silence-Induced Cell Death in Glioma Cells? [PDF]

, 2014
The molecular chaperone heat shock protein 90 alpha (Hsp90α) has been recognized in various tumours including glioma. This pilot study using a proteomic approach analyses the downstream effects of Hsp90 inhibition using 17-allylamino-17 ...
Khan, Zarine Jamsher, Munje, Chinmay, Shervington, Amal A, Shervington, Leroy Alexander   +3 more
core   +2 more sources

A Novel Therapeutic Strategy for the Treatment of Glioma, Combining Chemical and Molecular Targeting of Hsp90a [PDF]

, 2011
Hsp90α's vital role in tumour survival and progression, together with its highly inducible expression profile in gliomas and its absence in normal tissue and cell lines validates it as a therapeutic target for glioma.
Adi Mehta, Altieri, Amal Shervington, Bagatell, Basso, Bisht, Boado, Brader, Braga-Basaria, Burger, Chang, Chatterjee, Chinmay Munje, Chiosis, Clarke, Cohen-Saidon, Cruickshanks, Duerfeldt, Elbashir, Eustace, Gaspar, Gazitt, Goetz, Graner, Han, Isaacs, Jane, Kamal, Kamal, Karkoulis, Koren, Kumar, Lang, Lanneau, Leroy Shervington, Li, Luo, McAnuff, McCollum, Padmini, Porter, Pu, Pu, Sauvageot, Schiffelers, Shervington, Shim, Siegelin, Solit, Sreedhar, Stommel, Walsh, Whitesell, Yang, Yen, Yu   +55 more
core   +2 more sources

Chaperone expression profiles correlate with distinct physiological states of Plasmodium falciparum in malaria patients

Malaria Journal, 2010
Background Molecular chaperones have been shown to be important in the growth of the malaria parasite Plasmodium falciparum and inhibition of chaperone function by pharmacological agents has been shown to abrogate parasite growth.
Pallavi Rani, Acharya Pragyan, Chandran Syama, Daily Johanna P, Tatu Utpal   +4 more
doaj   +1 more source

Does native Trypanosoma cruzi calreticulin mediate growth inhibition of a mammary tumor during infection? [PDF]

, 2016
Indexación: Web of Science.Background: For several decades now an antagonism between Trypanosoma cruzi infection and tumor development has been detected. The molecular basis of this phenomenon remained basically unknown until our proposal that T.
A Colombo, A Morello, A Morillo, Arturo Ferreira, B Berwin, C Junqueira, C Ribeiro, C Valck, Carlos González, Carlos Rosas, E Sosoniuk, FJ Sánchez, FJ Sánchez, G Ramirez, G Ramírez, G Ramírez, Galia Ramírez, H Adachi, Ismael Maldonado, J Canton, J Clayton, Javier Pizarro-Bauerle, JC Aguillon, JC Aguillon, JD Maya, Jorge Ferreira, K Ahn, L Aguilar, L Aguilar, L Ubillos, Lorena Aguilar-Guzmán, M Michalak, M Obeid, M Pavani, MF Festing, NC López, Paula Abello-Cáceres, R Ramos, RH Berg Van den, V Ferreira, V Toledo, VD Kallinikova, Z Batmonkh   +42 more
core   +1 more source

Polysaccharide-based self-assembling nanohydrogels: An overview on 25-years research on pullulan [PDF]

, 2015
The aim of this overview is to review the evolution of the studies carried out, during more than 25 years, on nanohydrogels obtained by self-assembling of pullulan (PUL) using several hydrophobization strategies.
ALHAIQUE, Franco, COVIELLO, Tommasina, DI MEO, Chiara, MATRICARDI, PIETRO, MONTANARI, ELITA   +4 more
core   +1 more source