Results 41 to 50 of about 129,105 (287)

The structure, molecular interactions and bioactivities of proinsulin C-peptide correlate with a tripartite molecule

Biomolecular Concepts, 2014
Many biological roles have been assigned to proinsulin C-peptide over the years. Some appear surprisingly disparate and sometimes even contradictory, like chaperone-like actions and depository tendencies.
Landreh Michael, Johansson Jan, Wahren John, Jörnvall Hans   +3 more
doaj   +1 more source

The Factor VII Variant p.A354V-p.P464Hfs: Clinical versus Intracellular and Biochemical Phenotypes Induced by Chemical Chaperones [PDF]

Applied Sciences, 2021
(1) Background: Congenital factor (F) VII deficiency is caused by mutations in the F7 gene. Patients with modest differences in FVII levels may display large differences in clinical severity. The variant p.A354V-p.P464Hfs is associated with reduced FVII antigen and activity.
Andersen, Elisabeth, Chollet, Maria Eugenia, Bernardi, Francesco, Branchini, Alessio, Baroni, Marcello, Mariani, Guglielmo, Dolce, Alberto, Batorova, Angelika, Skarpen, Ellen, Myklebust, Christiane Filion, Skretting, Grethe, Sandset, Per Morten   +11 more
openaire   +4 more sources

Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. [PDF]

, 2016
Mutations in human CLC-1 chloride channel are associated with the skeletal muscle disorder myotonia congenita. The disease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1.
Chen, Shu-Ching, Chen, Tsung-Yu, Hsieh, Hsin-Ying, Huang, Jing-Jia, Peng, Yi-Jheng, Tang, Chih-Yung, Wu, Chia-Ying, Wu, Hao-Han   +7 more
core   +1 more source

Prognostic and Clinical Values of Chaperone Protein P4HB in Malignant Glioma

, 2021
Abstract Introduction. Prolyl 4-hydroxylase, beta polypeptide (P4HB) has previously been identified by our group to play important roles in association with glioma malignancy and temozolomide (TMZ) resistance through the unfolded protein response (UPR). The present study focused on the prognostic value of P4HB in glioma. Methods.
Stella Sun, Karrie Mei-Yee Kiang, Gilberto Ka-Kit Leung   +2 more
openaire   +1 more source

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure [PDF]

, 2015
Hepatocellular carcinoma (HCC) is characterized by the accumulation of unfolded proteins in the endoplasmic reticulum (ER), which activates the unfolded protein response (UPR).
Ampe, Christophe, Bogaerts, Eliene, Descamps, Benedicte, Devisscher, Lindsey, Geerts, Anja, Govaere, O, Laukens, Debby, Libbrecht, Louis, Paridaens, Annelies, Raevens, Sarah, Van den Bussche, A, Van Steenkiste, Christophe, Van Troys, Marleen, Van Vlierberghe, Hans, Vandewynckel, Yves-Paul, Vanhove, Christian, Verhelst, Xavier   +16 more
core   +3 more sources

The chaperone DnaK promotes the emergence and accumulation of antibiotic-resistant clones through its ATPase activity in Riemerella anatipestifer

Poultry Science
The rapid emergence of antibiotic-resistant bacteria has become a global concern. In particular, the overuse of antibiotics in the breeding industry has accelerated the emergence of antibiotic-resistant bacteria, but the mechanisms driving this ...
Fang Guo, Chunfeng Shi, Li Huang, Yizhou Yao, Liping Qiao, Dekang Zhu, Mingshu Wang, Renyong Jia, Shun Chen, Xinxin Zhao, Ying Wu, Shaqiu Zhang, Ling Zhang, Yanling Yu, Friedrich Götz, Anchun Cheng, Mafeng Liu   +16 more
doaj   +1 more source

Chaperone activity of serine protease HtrA of Helicobacter pylori as a crucial survival factor under stress conditions

Cell Communication and Signaling, 2019
Background Serine protease HtrA exhibits both proteolytic and chaperone activities, which are involved in cellular protein quality control. Moreover, HtrA is an important virulence factor in many pathogens including Helicobacter pylori, for which the ...
Urszula Zarzecka, Aileen Harrer, Anna Zawilak-Pawlik, Joanna Skorko-Glonek, Steffen Backert   +4 more
doaj   +1 more source

Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]

, 2011
Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
core   +1 more source

Chaperonopathies: spotlight on hereditary motor neuropathies

Frontiers in Molecular Biosciences, 2016
Distal hereditary motor neuropathies (dHMN) comprise a group of rare hereditary neuromuscular disorders characterized by a peroneal muscular atrophy without sensory symptoms.
Vincenzo Lupo, Vincenzo Lupo, Carmen Aguado, Carmen Aguado, Carmen Aguado, Erwin Knecht, Erwin Knecht, Erwin Knecht, Carmen Espinós, Carmen Espinós   +9 more
doaj   +1 more source

Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics [PDF]

Open Biology, 2012
Heat shock protein 90 (Hsp90) is a promising cancer drug target as a molecular chaperone critical for stabilization and activation of several of the oncoproteins that drive cancer progression.
Peter W. Piper, Stefan H. Millson
doaj   +1 more source