The Secreted Acid Phosphatase Domain-Containing GRA44 from Toxoplasma gondii Is Required for c-Myc Induction in Infected Cells. [PDF]
, 2020 During host cell invasion, the eukaryotic pathogen Toxoplasma gondii forms a parasitophorous vacuole to safely reside within the cell, while it is partitioned from host cell defense mechanisms.
Arrizabalaga, Gustavo +2 more
core +2 more sources
Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells. [PDF]
, 2008 Hsp60, a mitochondrial chaperonin highly conserved during evolution, has been found elevated in the cytosol of cancer cells, both in vivo and in vitro, but its role in determining apoptosis during oxidative stress (OS) has not yet been fully elucidated ...
Ardizzone, NM +17 more
core +2 more sources
RNA interference approaches for treatment of HIV-1 infection. [PDF]
, 2015 HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L +2 more
core +1 more source
Molecular chaperones are nanomachines that catalytically unfold misfolded and alternatively folded proteins. [PDF]
, 2014 By virtue of their general ability to bind (hold) translocating or unfolding polypeptides otherwise doomed to aggregate, molecular chaperones are commonly dubbed "holdases".
Goloubinoff, P., Mattoo, R.U.
core +2 more sources
Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C-elegans [PDF]
, 2018 Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. In Caenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced ...
AN, SEON WOO +15 more
core +1 more source
Volatile compounds emitted by diverse phytopathogenic microorganisms promote plant growth and flowering through cytokinin action [PDF]
, 2016 Sánchez-López, Ángela María et al.It is known that volatile emissions from some beneficial rhizosphere microorganisms promote plant growth. Here we show that volatile compounds (VCs) emitted by phylogenetically diverse rhizosphere and non-rhizhosphere ...
Almagro, Goizeder +8 more
core +1 more source
Nuclear functions of prefoldin [PDF]
, 2014 Prefoldin is a cochaperone, present in all eukaryotes, that cooperates with the chaperonin CCT. It is known mainly for its functional relevance in the cytoplasmic folding of actin and tubulin monomers during cytoskeleton assembly. However, both canonical
Chávez de Diego, Sebastián +1 more
core +1 more source
Essential Genetic Interactors of SIR2 Required for Spatial Sequestration and Asymmetrical Inheritance of Protein Aggregates [PDF]
, 2014 Sir2 is a central regulator of yeast aging and its deficiency increases daughter cell inheritance of stress-and aging-induced misfolded proteins deposited in aggregates and inclusion bodies.
Cvijovic, Marija +12 more
core +3 more sources
Advanced Science, Volume 13, Issue 20, 9 April 2026.Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin +12 more
wiley +1 more source
Acetyl‐Phosphate Dependent Protein Acetylation in Neisseria gonorrhoeae
MicrobiologyOpen, Volume 15, Issue 2, April 2026.The role of acetyl‐phosphate‐dependent non‐enzymatic protein acetylation in Neisseria gonorrhoeae was investigated through the deletion of the phosphotransacetylase (pta) and the acetate kinase (ackA) genes, this led to a decrease and increase in protein acetylation, respectively.
Ernesto F. D. Parga +6 more
wiley +1 more source