Results 11 to 20 of about 746 (85)
Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery
PROTEOMICS, Volume 25, Issue 21-22, Page 102-150, November 2025.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam +12 more
wiley +1 more source
Advanced Science, Volume 12, Issue 38, October 13, 2025.Here, it is revealed that CAF‐secreted exosomal CCT6A enhances stemness, chemoresistance, and glycolysis in GC via the β‐catenin/c‐Myc/DDIT4‐TXNIP axis. Furthermore, CCT6P1, a pseudogene of CCT6A, is identified as upregulating CCT6A by competitively binding miR‐922, while c‐Myc transcriptionally activates both CCT6P1 and CCT6A.
Hui Sun +15 more
wiley +1 more source
HemaSphere, Volume 9, Issue 9, September 2025.Abstract Platelets are anucleate cells produced in the bone marrow and derived from large progenitor cells called megakaryocytes (MKs). Platelets receive RNA transcripts from their progenitorial MKs during thrombopoiesis. However, the correspondence between platelet and MK transcriptomes is poorly understood, particularly in the context of germline ...
Koenraad De Wispelaere +7 more
wiley +1 more source
Quorum Sensing via Autoinducer‐2 Promotes Colonisation and Host Adaptation in B. bifidum PRL2010
Microbial Biotechnology, Volume 18, Issue 9, September 2025.Autoinducer‐2 (AI‐2), encoded by the luxS gene, is a molecule involved in the quorum sensing mechanism in bifidobacteria, typical intestinal bacteria. In this manuscript, the distribution of this gene in all bifidobacterial genomes deposited in the database has been studied.
Francesca Turroni +11 more
wiley +1 more source
The FEBS Journal, Volume 292, Issue 6, Page 1316-1329, March 2025.This work investigates the archaeome, an essential segment of the human microbiome, focusing on its relationship with the immune system. Here, we outline the types of archaea across different body areas and underscore possible links to health issues, such as obesity and specific cancers.
Torben Kuehnast +5 more
wiley +1 more source
International Journal of Cancer, Volume 156, Issue 3, Page 623-637, 1 February 2025.What's new? 14‐3‐3σ functions as an oncogene in colorectal cancer and is associated with therapy resistance. However, the underlying mechanisms remain unclear. Here, the authors show that 14‐3‐3σ restricts the localization of the transcription factor YY1 to the cytoplasm, preventing it from repressing genes of the unfolded protein response pathway ...
Amol Lonare +8 more
wiley +1 more source
Microbial Biotechnology, Volume 18, Issue 2, February 2025.The dogma on the heat shock DnaK chaperone establishes its fundamental cytosolic role in folding and unfolding intracellular proteins. This study reveals its tight association with the flagellin, its secretion, likely through the flagellum apparatus, its insertion into a growing flagellum filament and a novel extracellular ATP‐independent chaperone ...
Gabriella Molinari +17 more
wiley +1 more source
The Journal of Clinical Hypertension, Volume 27, Issue 1, January 2025.Abstract Resistant hypertension (RH) may cause severe target organ damage and poses significant challenges in the field of hypertension prevention and treatment. Mining biological characteristics is crucial for exploring the pathogenesis of RH and for early diagnosis and treatment.
Shanshan Wang +8 more
wiley +1 more source
Surface-exposed chaperonin 60 derived from Propionibacterium freudenreichii MJ2 inhibits adipogenesis by decreasing the expression of C/EBPα/PPARγ. [PDF]
Sci Rep, 2023 An M, Lim YH.
europepmc +1 more source