Results 101 to 110 of about 1,736,810 (289)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The Prominence of Pippin [PDF]
, 2015 When building a fictional world as involved and vast as that of J.R.R. Tolkien’s multiple drafts are a must in order to work out the exact details and to make sure that all the possible loose ends are tied up and addressed.
Sunderlage, Jasmine
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Building Smart Embodied Virtual Characters [PDF]
, 2003 Embodied conversational characters are autonomous, graphically embodied virtual creatures that live in a 2D or 3D virtual environment. They are able to interact intelligently with human users, other characters, and their digital environment. While for decades research has concentrated on geometric body modelling and the development of animation and ...
Rist, Thomas, André, Elisabeth
openaire +2 more sources
Building a Better Character Model: The Art and Process of Character Design [PDF]
, 2016 The art and process of character design flows from understanding the world a character lives in and how that world affects his or her actions, personality, and storyline, and also inspires a character\u27s dress, poses, and accouterments. This thesis was
Mitchell, Sarah K
core
Character sums to smooth moduli are small
, 2007 Recently, Granville and Soundararajan have made fundamental breakthroughs in the study of character sums. Building on their work and using estimates on short character sums developed by Graham-Ringrose and Iwaniec, we improve the Polya-Vinogradov ...
Davenport +12 more
core +2 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source