An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
High performance building envelopes with retro-reflective materials
, 2017 Highly reflective materials have been proposed as a strategy for energy consumption reduction in buildings and outdoor comfort improvement (i.e. urban heat island mitigation).
CASTELLANI, BEATRICE +4 more
core
An assessment of teacher perceptions of attitudes toward character education [PDF]
, 2002 Plan BCharacter education means many things to different people. Thomas Lickona, a founder in the current character education movement, in believes it is essentially respect and responsibility.
Bever, Julie A.
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Building Schools of Character: The Development, Implementation, and Evaluation of a School-Based Character Education Programme Designed to Promote Cooperative Learning and Reduce Anti-Social Behaviour [PDF]
, 2010 Background: The issue of behaviour management, particularly as it pertains to addressing anti-social behaviour and improving learning and life outcomes for children and adolescents in schools has become a primary topic of discussion among educational ...
WHITE, ROBERT,MICHAEL
core
MATHEMATICS AS A FACTOR IN CHARACTER BUILDING* [PDF]
School Science and Mathematics, 1907 n ...
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Character and Character Swapping in Mozart’s Così fan tutte
, 2016 This chapter on Mozart’s opera Così fan tutte (“Thus Do They All”) offers a discussion of a number of topics covered by other chapters—the portrayal of fictional characters, mixed motivation, promise keeping, the influence of character, and situational ...
Stephen Davies, Davies, Stephen
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source