Results 31 to 40 of about 169,983 (336)

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Dataset of TPACK in teaching practice: Adversity quotient, attitude computer technology and self-efficacy among Indonesian teachers

Data in Brief, 2022
This dataset describes the measurement of adversity quotient (AQ), attitude computer technology (ACT), and self-efficacy with computer technology (SCT) of Indonesian teachers in implementing the technological pedagogical content knowledge (TPACK) concept
Wibowo Heru Prasetiyo, Beti Indah Sari, Noor Banu Mahadir Naidu, Halimah Sa'diyah, Rizky Novia Saputri, Jagad Aditya Dewantara, Patmisari   +6 more
doaj  

Generative AI for learning: Investigating the potential of synthetic learning videos [PDF]

arXiv, 2023
Recent advances in generative artificial intelligence (AI) have captured worldwide attention. Tools such as Dalle-2 and ChatGPT suggest that tasks previously thought to be beyond the capabilities of AI may now augment the productivity of creative media in various new ways, including through the generation of synthetic video.
arxiv  

Expounding on physics -- A phenomenographic study of physicists talking of their physics [PDF]

International Journal of Science Education, Volume 25, No. 12, Pages 1489-1508 (2003), 2002
Physicists and physics students have been studied with respect to the variation in ways they expound on their topic of research and a physics problem, respectively. A phenomenographic approach has been employed; six fourth-year physics students and ten teacher/researcher physicists at various stages of their careers have been interviewed.
arxiv   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

STRATEGI PEMBENTUKAN KARAKTER SISWA PADA JENJANG PENDIDIKAN DASAR MELALUI MATA PELAJARAN PENDIDIKAN JASMANI OLAHRAGA DAN KESEHATAN

Premiere, 2021
The rapid development of science , knowledge , technology and information systems make the impact positive and negative impact on education world. An effort to reduce the negative effect of technology appliance on education is by applying character-based
Akhmad Aji Pradana
doaj   +1 more source

Early Childhood Character Education in Japan [PDF]

E3S Web of Conferences, 2020
Character education has a very important role in shaping the superior character of Japanese society. Compared to Indonesia, Japan has long designed and implemented character education for all levels of education.
Mulyadi Budi
doaj   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Modeling the EdNet Dataset with Logistic Regression [PDF]

AAAI 2021 Workshop on AI in Education, 2021
Many of these challenges are won by neural network models created by full-time artificial intelligence scientists. Due to this origin, they have a black-box character that makes their use and application less clear to learning scientists. We describe our experience with competition from the perspective of educational data mining, a field founded in the
arxiv