Results 121 to 130 of about 104,796 (258)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

VI-OCR: "Visually Impaired" optical character recognition pipeline for text accessibility assessment. [PDF]

Sci Rep
Gao Q, Manduchi R, Ramulu PY, Legge GE, Xiong Y.   +4 more
europepmc   +1 more source

Some neighbors are more interfering: Asymmetric priming by stroke neighbors in Chinese character recognition. [PDF]

Psychon Bull Rev, 2023
Yu L, Zhang Q, Ke M, Han Y, Kinoshita S.
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

SVTR-MG: an optical character recognition network for food packaging spray codes. [PDF]

Sci Rep
Pan S, Wang P.
europepmc   +1 more source

PF-ViT: Parallel and Fast Vision Transformer for Offline Handwritten Chinese Character Recognition. [PDF]

Comput Intell Neurosci, 2022
Dan Y, Zhu Z, Jin W, Li Z.
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

OCRNet a robust deep learning framework for alphanumeric character recognition to assist the visually impaired. [PDF]

Sci Rep
Nagasubramanian A, Almazyad AS, Balakrishnan SA, Mm BR, Potti D, Zakariah M, AlSekait DM.   +6 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

MallaNet residual branch merge convolutional neural network with homogeneous filter capsules for Devanagari character recognition. [PDF]

Sci Rep
Malla SR.
europepmc   +1 more source